The HLA region and autoimmune disease: associations and mechanisms of action
MJ Simmonds, SCL Gough - Current genomics, 2007 - ingentaconnect.com
The HLA region encodes several molecules that play key roles in the immune system.
Strong association between the HLA region and autoimmune disease (AID) has been …
Strong association between the HLA region and autoimmune disease (AID) has been …
HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile
AK Mangalam, V Taneja, CS David - The Journal of Immunology, 2013 - journals.aai.org
The MHC in humans encodes the most polymorphic genes, the HLA genes, which are
critical for the immune system to clear infection. This can be attributed to strong selection …
critical for the immune system to clear infection. This can be attributed to strong selection …
The Influence of HLA Genotype on AIDS
M Carrington, SJ O'Brien - Annual review of medicine, 2003 - annualreviews.org
Genetic resistance to infectious diseases is likely to involve a complex array of immune-
response and other genes with variants that impose subtle but significant consequences on …
response and other genes with variants that impose subtle but significant consequences on …
What has GWAS done for HLA and disease associations?
AE Kennedy, U Ozbek, MT Dorak - International journal of …, 2017 - Wiley Online Library
The major histocompatibility complex (MHC) is located in chromosome 6p21 and contains
crucial regulators of immune response, including human leucocyte antigen (HLA) genes …
crucial regulators of immune response, including human leucocyte antigen (HLA) genes …
[HTML][HTML] Contribution of a non-classical HLA gene, HLA-DOA, to the risk of rheumatoid arthritis
Despite the progress in human leukocyte antigen (HLA) causal variant mapping,
independent localization of major histocompatibility complex (MHC) risk from classical HLA …
independent localization of major histocompatibility complex (MHC) risk from classical HLA …
Relative expression levels of the HLA class-I proteins in normal and HIV-infected cells
The expression level of HLA class-I proteins is known to influence pathological outcomes:
pathogens downregulate HLA to evade host immune responses, host inflammatory …
pathogens downregulate HLA to evade host immune responses, host inflammatory …
HLA genomics in the third millennium
J Trowsdale - Current opinion in Immunology, 2005 - Elsevier
The MHC region contains several unique characteristics that set it apart as the most
important region in the vertebrate genome in relation to disease. Recent data fit with the long …
important region in the vertebrate genome in relation to disease. Recent data fit with the long …
[HTML][HTML] Human leukocyte antigen (HLA) and immune regulation: how do classical and non-classical HLA alleles modulate immune response to human …
NB Crux, S Elahi - Frontiers in immunology, 2017 - frontiersin.org
The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …
involve a sophisticated array of immune response. These genetic elements may modulate …
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
The genetic association of the major histocompatibility complex (MHC) to rheumatoid
arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate …
arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate …
[HTML][HTML] The HLA genomic loci map: expression, interaction, diversity and disease
T Shiina, K Hosomichi, H Inoko, JK Kulski - Journal of human genetics, 2009 - nature.com
The human leukocyte antigen (HLA) super-locus is a genomic region in the chromosomal
position 6p21 that encodes the six classical transplantation HLA genes and at least 132 …
position 6p21 that encodes the six classical transplantation HLA genes and at least 132 …