Many believe that engaging in novel and mentally challenging activities promotes brain
health and prevents Alzheimer's disease in later life. However, mental stimulation may also …

Noradrenergic neurons in the locus coeruleus play a role in learning and memory, and their
loss is an early event in Alzheimer's disease pathogenesis. Moreover, noradrenaline may …

Alzheimer's disease (AD) poses a significant global health concern over the next several
decades. Multiple hypotheses have been put forth that attempt to explain the underlying …

Loss of Locus coeruleus (LC) noradrenergic (NA) neurons occurs in several
neurodegenerative conditions including Alzheimer's disease (AD). In vitro and in vivo …

Advanced Alzheimer's disease (AD) is characterized by higher noradrenaline metabolite
levels that may be associated with AD pathology. The locus coeruleus (LC) is the main site …

In the past, manipulation of the cholinergic system was seen as the most likely therapeutic
for neurodegeneration-based cognitive decline in Alzheimer's disease (AD)(Whitehouse et …

A growing body of evidence demonstrates the important role of the noradrenergic system in
the pathogenesis of many neurodegenerative processes, especially Alzheimer's disease …

J. Neurochem.(2010) 113, 649–660. Abstract Degeneration of locus coeruleus (LC)
noradrenergic forebrain projection neurons is an early feature of Alzheimer's disease. The …

The brain noradrenergic system supplies the neurotransmitter norepinephrine throughout
the brain via widespread efferent projections, and plays a pivotal role in modulating …

Neuromodulation regulates critical functions of CNS synapses, ranging from neural circuit
development to high-order cognitive processes, including learning and memory. This broad …