[HTML][HTML] Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p
L Zhu, Q Zhong, T Yang, X Xiao - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent
metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) …
metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) …
[HTML][HTML] Suppression of microRNA-205-5p in human mesenchymal stem cells improves their therapeutic potential in treating diabetic foot disease
L Zhu, G Wang, S Fischbach, X Xiao - Oncotarget, 2017 - ncbi.nlm.nih.gov
Diabetes is a prevalent disease endangering human health, while diabetic foot disease (DF)
is one of the most severe complications of diabetes. Mesenchymal stem cells (MSCs) have …
is one of the most severe complications of diabetes. Mesenchymal stem cells (MSCs) have …
Stem cell therapy with CRISPR/Cas9-mediated MALAT1 delivery modulates miR-142 and rescues wound healing in rats with age-associated diabetic foot ulcers
R Shi, C Chen, S Zhao, H Yuan, J Zhao… - Archives of Gerontology …, 2024 - Elsevier
Background Diabetic foot ulcer (DFU) is a serious diabetes complication, significantly
impacting the quality of life, particularly in the elderly. Age-associated DFUs pose additional …
impacting the quality of life, particularly in the elderly. Age-associated DFUs pose additional …
[PDF][PDF] LncRNA MALAT1 facilities high glucose induced endothelial to mesenchymal transition and fibrosis via targeting miR-145/ZEB2 axis.
B Liu, L Qiang, GD Wang, Q Duan… - European Review for …, 2019 - europeanreview.org
OBJECTIVE: Diabetic nephropathy (DN) is one of the most common complications of
diabetes mellitus (DM), but the pathophysiology of DN is complex and not fully understood …
diabetes mellitus (DM), but the pathophysiology of DN is complex and not fully understood …
Identification of the MALAT1/miR-106a-5p/ZNF148 Feedback Loop in Regulating HaCaT Cell Proliferation, Migration and Apoptosis
LW Kuang, CC Zhang, BH Li, HZ Liu… - Regenerative …, 2023 - Taylor & Francis
Aims: This study aims to investigate the function of positive feedback loops involving
noncoding RNA in diabetic wound healing. Methods: We developed a mouse diabetic …
noncoding RNA in diabetic wound healing. Methods: We developed a mouse diabetic …
[HTML][HTML] Human mesenchymal stem cells promote ischemic repairment and angiogenesis of diabetic foot through exosome miRNA-21-5p
C Huang, W Luo, Q Wang, Y Ye, J Fan, L Lin, C Shi… - Stem Cell Research, 2021 - Elsevier
Background Diabetic foot is caused by ischemic disease of lower extremities of diabetic
patients, and the effective therapy is very limited. Mesenchymal stem cells (MSCs) based …
patients, and the effective therapy is very limited. Mesenchymal stem cells (MSCs) based …
Long non‐coding RNA MALAT1 promotes proliferation, angiogenesis, and immunosuppressive properties of mesenchymal stem cells by inducing VEGF and IDO
X Li, Y Song, F Liu, D Liu, H Miao, J Ren… - Journal of cellular …, 2017 - Wiley Online Library
Mesenchymal stem cells (MSCs) play an important role in regulating angiogenesis and
immune balance. The abnormal MSCs in proliferation and function were reported at …
immune balance. The abnormal MSCs in proliferation and function were reported at …
[HTML][HTML] Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis
Patients with peripheral artery disease (PAD) and diabetes compose a high-risk population
for development of critical limb ischemia (CLI) and amputation, although the underlying …
for development of critical limb ischemia (CLI) and amputation, although the underlying …
Deregulation of microRNA-503 contributes to diabetes mellitus–induced impairment of endothelial function and reparative angiogenesis after limb ischemia
A Caporali, M Meloni, C Völlenkle, D Bonci… - Circulation, 2011 - Am Heart Assoc
Background—Diabetes mellitus impairs endothelial cell (EC) function and postischemic
reparative neovascularization by molecular mechanisms that are not fully understood …
reparative neovascularization by molecular mechanisms that are not fully understood …
MicroRNA miR-27b rescues bone marrow–derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus
Objective—Vascular precursor cells with angiogenic potentials are important for tissue
repair, which is impaired in diabetes mellitus. MicroRNAs are recently discovered key …
repair, which is impaired in diabetes mellitus. MicroRNAs are recently discovered key …