Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome

J Zhao, J Wang, M Zhou, M Li, M Li, H Tan - International …, 2019 - Elsevier
Despite rapid progress in the understanding of systemic lupus erythematosus (SLE), there is
still an urgent need for novel and more effective interventions. Curcumin, a natural …

Curcumin attenuates autoimmunity and renal injury in an experimental model of systemic lupus erythematosus

EL Dent, EB Taylor, HR Turbeville… - Physiological …, 2020 - Wiley Online Library
Systemic lupus erythematosus (SLE) is an autoimmune disorder with prevalent hypertension
and renal disease. To avoid side effects of immunosuppressive drugs, alternative therapies …

Curcumin suppresses IL-1β secretion and prevents inflammation through inhibition of the NLRP3 inflammasome

H Yin, Q Guo, X Li, T Tang, C Li, H Wang… - The Journal of …, 2018 - journals.aai.org
Turmeric is traditionally used as a spice and coloring in foods. Curcumin is the primary
active ingredient in the turmeric, and compelling evidence has shown that it has the ability to …

Curcumin prevents osteoarthritis by inhibiting the activation of inflammasome NLRP3

Y Sun, W Liu, H Zhang, H Li, J Liu, F Zhang… - Journal of Interferon & …, 2017 - liebertpub.com
Curcumin has shown protective potential on osteoarthritis. However, its effect on treatment of
osteoarthritis remains elusive so far. This study aimed to determine whether curcumin could …

Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice

H Lee, H Kim, G Lee, HS Chung, H Bae - British journal of nutrition, 2013 - cambridge.org
Curcumin has been used in Asian traditional medicine for its medicinal properties. Recent
studies have demonstrated that curcumin has antioxidant, anti-tumour and anti-inflammatory …

Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus

S Foxley, M Zamora, B Hack, RR Alexander, B Roman… - Brain research, 2013 - Elsevier
Complement activation and inflammation are key disease features of systemic lupus
erythematosus. Curcumin is an anti-inflammatory agent that inhibits the complement …

Curcumin: A natural modulator of immune cells in systemic lupus erythematosus

AA Momtazi-Borojeni, SM Haftcheshmeh… - Autoimmunity …, 2018 - Elsevier
Curcumin is a polyphenol natural product isolated from turmeric, interacting with different
cellular and molecular targets and, consequently, showing a wide range of pharmacological …

Curcumin ameliorates monosodium urate‐induced gouty arthritis through Nod‐like receptor 3 inflammasome mediation via inhibiting nuclear factor‐kappa B signaling

X Li, DQ Xu, DY Sun, T Zhang, X He… - Journal of Cellular …, 2019 - Wiley Online Library
Background Monosodium urate (MSU) crystals‐induced inflammation is a key initiator in
gouty arthritis. Curcumin is an active ingredient possessing anti‐inflammatory efficacy. But …

Curcumin attenuates both acute and chronic immune nephritis

T Wu, B Marakkath, Y Ye, E Khobahy, M Yan… - International journal of …, 2020 - mdpi.com
Curcumin is known to have immunomodulatory potential in addition to anti-oxidant, anti-
inflammatory and anti-carcinogenic effects. The aim of the present study is to investigate the …

Curcumin ameliorates diabetic nephropathy by suppressing NLRP3 inflammasome signaling

M Lu, N Yin, W Liu, X Cui, S Chen… - BioMed research …, 2017 - Wiley Online Library
Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease, partly because
of the lack of effective treatments for DN. Curcumin has been shown to exert strong …