Development of a novel cervix-inspired tortuous microfluidic system for efficient, high-quality sperm selection

E Dadkhah, MA Hajari, S Abdorahimzadeh… - Lab on a Chip, 2023 - pubs.rsc.org
Microfluidic systems have been extensively studied in recent years as potential alternatives
for problematic conventional methods of sperm selection. However, despite the widespread …

Selection of high-quality sperm with thousands of parallel channels

M Simchi, J Riordon, JB You, Y Wang, S Xiao… - Lab on a Chip, 2021 - pubs.rsc.org
Sperm selection is essential for successful fertilization and embryo development. Current
clinical sperm selection methods are labor-intensive and lack the selectivity required to …

Exhaustion of racing sperm in nature‐mimicking microfluidic channels during sorting

S Tasoglu, H Safaee, X Zhang, JL Kingsley… - Small, 2013 - Wiley Online Library
The World Health Organization (WHO) estimates approximately 70 million couples
experience infertility worldwide.[1–4] Current data suggests that nearly one third of these …

Sperm-like-particle (SLP) behavior in curved microfluidic channels

J Son, AR Jafek, DT Carrell, JM Hotaling… - Microfluidics and …, 2019 - Springer
Microfluidic technology has the potential to separate sperm cells from unwanted debris
commonly found in clinical samples while improving the effectiveness of assisted …

Can Microfluidics Improve Sperm Quality? A Prospective Functional Study

F Meseguer, C Giménez Rodríguez, R Rivera Egea… - Biomedicines, 2024 - mdpi.com
The same sperm selection techniques in assisted reproduction clinics have remained
largely unchanged despite their weaknesses. Recently, microfluidic devices have emerged …

Progressive bovine sperm separation using parallelized microchamber-based microfluidics

M Yaghoobi, M Azizi, A Mokhtare, A Abbaspourrad - Lab on a Chip, 2021 - pubs.rsc.org
Motility is one of the most important factors in sperm migration toward an egg. Therefore,
sperm separation based on motility might enhance sperm selection for infertility treatments …

Optimization of Dean flow microfluidic chip for sperm preparation for intrauterine insemination

A Jafek, H Feng, D Broberg, B Gale, R Samuel… - Microfluidics and …, 2020 - Springer
Sperm preparation is a necessary step in all methods of assisted reproductive technology.
Here, we demonstrate the utility of a microfluidic spiral channel device for preparation of …

Sperm quality metrics were improved by a biomimetic microfluidic selection platform compared to swim-up methods

SA Vasilescu, L Ding, FY Parast, R Nosrati… - Microsystems & …, 2023 - nature.com
Sperm selection is an essential component of all assisted reproductive treatments (ARTs)
and is by far the most neglected step in the ART workflow in regard to technological …

Microfluidic sorting selects sperm for clinical use with reduced DNA damage compared to density gradient centrifugation with swim-up in split semen samples

MM Quinn, L Jalalian, S Ribeiro, K Ona… - Human …, 2018 - academic.oup.com
STUDY QUESTION Does microfluidic sorting improve the selection of sperm with lower DNA
fragmentation over standard density-gradient centrifugation? SUMMARY ANSWER …

Rapid selection of sperm with high DNA integrity

R Nosrati, M Vollmer, L Eamer, MC San Gabriel… - Lab on a Chip, 2014 - pubs.rsc.org
Sperm selection is essential to assisted reproductive technology (ART), influencing
treatment outcomes and the health of offspring. The fundamental challenge of sperm …