Tumor cells harbor tens to thousands of genetic and epigenetic alterations that disrupt
cellular pathways, providing them with growth and survival advantages. However, these …

Tumour mutations corrupt cellular pathways, and accumulate to disrupt, dysregulate, and
ultimately avoid mechanisms of cellular control. Yet the very changes that tumour cells …

As a promising therapeutic strategy, oncolytic virotherapy has shown potent anticancer
efficacy in numerous pre-clinical and clinical trials. Oncolytic viruses have the capacity for …

Over the past 1–2 decades we have witnessed a resurgence of efforts to therapeutically
exploit the attributes of lytic viruses to infect and kill tumor cells while sparing normal cells …

Cancer is a traitorous archenemy that threatens our survival. Its ability to evade detection
and adapt to various cancer therapies means that it is a moving target that becomes …

Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate
preferentially in tumor cells and inhibit tumor growth. These viruses have been considered …

Oncolytic viruses consist of a diverse range of DNA and RNA viruses traditionally thought to
mediate their effects by exploiting aberrations in tumor pathways, allowing preferential viral …

Oncolytic viruses (OVs) are replication competent agents that selectively target cancer cells.
After penetrating the tumor cell, viruses replicate and eventually trigger cell lysis, releasing …

Oncolytic virotherapy is emerging as a promising approach for the treatment of several
neoplasms. The term “oncolytic viruses” is generally employed to indicate naturally …

Oncolytic viruses can selectively replicate in and lead to tumor cell lysis with minimal
infection/replication potential in adjoining non-neoplastic tissue. Because of paramount …