The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

Several benefits can be acquired through physical exercise. Different classes of
biomolecules are responsible for the cross-talk between distant organs. The secretome of …

Exercise confers numerous salutary effects that extend beyond individual organ systems to
provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular …

Regular exercise is a formidable regulator of insulin sensitivity and overall systemic
metabolism through both acute events driven by each exercise bout and through chronic …

Exercise activates a plethora of metabolic and signalling pathways in skeletal muscle and
other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise …

Habitual endurance exercise training is associated with multisystemic metabolic adaptations
that lower the risk of inactivity-associated disorders such as obesity and type 2 diabetes …

We hypothesized that skeletal muscle contraction produces a cellular stress signal,
triggering adipose tissue lipolysis to sustain fuel availability during exercise. The present …

Physical exercise may improve cognitive function by modulating molecular and cellular
mechanisms within the brain. We propose that the facilitation of long-term synaptic …

Mechanistic insights into the molecular events by which exercise enhances the skeletal
muscle phenotype are lacking, particularly in the context of type 2 diabetes. Here, we …

Skeletal muscle is an endocrine organ that produces and releases myokines in response to
contraction. Some myokines are likely to work in a hormone-like fashion, exerting specific …