Donepezil-Loaded Nanocarriers for the Treatment of Alzheimer's Disease: Superior Efficacy of Extracellular Vesicles Over Polymeric Nanoparticles

R Oliveira Silva, H Counil, JM Rabanel… - International Journal …, 2024 - Taylor & Francis
Introduction Drug delivery across the blood-brain barrier (BBB) is challenging and therefore
severely restricts neurodegenerative diseases therapy such as Alzheimer's disease (AD) …

Design and biological evaluation of lipoprotein-based donepezil nanocarrier for enhanced brain uptake through oral delivery

KV Krishna, G Wadhwa, A Alexander… - ACS chemical …, 2019 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
memory and cognitive impairment. Donepezil is an acetylcholinesterase inhibitor used for …

Preparation, characterization, in vivo biodistribution and pharmacokinetic studies of donepezil-loaded PLGA nanoparticles for brain targeting

Bhavna, S Md, M Ali, S Baboota, JK Sahni… - Drug development …, 2014 - Taylor & Francis
Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disorder
manifested by cognitive, memory deterioration and variety of neuropsychiatric symptoms …

Alzheimer's disease targeted nano-based drug delivery systems

G Altinoglu, T Adali - Current Drug Targets, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is the most common neurodegenerative disease, and is part of a
massive and growing health care burden that is destroying the cognitive function of more …

Nanocarriers for Alzheimer's disease: research and patent update

K Pathak, SK Mishra, A Porwal… - Journal of Applied …, 2021 - japsonline.com
Alzheimer's disease (AD) is one of the most progressive neurodegenerative disorders
resulting in cognitive and behavioral impairment in individuals beyond 65 years of age. It is …

Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer's disease

R Taliyan, V Kakoty, KC Sarathlal… - Journal of Controlled …, 2022 - Elsevier
For the past several years, dementia, is one of the predominantly observed groups of
symptoms in a geriatric population. Alzheimer's disease (AD) is a progressive memory …

Multifunctional nanocarriers for Alzheimer's disease: befriending the barriers

MA Ansari, T Tripathi, B Venkidasamy, A Monziani… - Molecular …, 2024 - Springer
Neurodegenerative diseases (NDDs) have been increasing in incidence in recent years and
are now widespread worldwide. Neuronal death is defined as the progressive loss of …

New advances in brain-targeting nano-drug delivery systems for Alzheimer's disease

Q Ouyang, Y Meng, W Zhou, J Tong… - Journal of drug …, 2022 - Taylor & Francis
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide and its
incidence is increasing due to the ageing population. Currently, the main limitations of AD …

[HTML][HTML] Recent advances in brain delivery of synthetic and natural nano therapeutics: Reviving hope for Alzheimer's disease patients

DS Nady, U Bakowsky, SA Fahmy - Journal of Drug Delivery Science and …, 2023 - Elsevier
As the globe's population increases, the incidences of Alzheimer's disease (AD) are steadily
increasing. AD represents the most common neurological disorder and constitutes 60–70 …

Potential of drug-loaded nanoparticles for Alzheimer's disease: diagnosis, prevention and treatment

S Doggui, L Dao, C Ramassamy - Therapeutic delivery, 2012 - Taylor & Francis
Therapeutic Delivery (2012) 3 (9) 1026 future science group hampering their biodistribution.
Conversely, ζ potential, an indicator of the repulsive force between particles, will influence …