Prolonged culture of metaphase II oocytes is an in vitro aging process that compromises
oocyte quality. We tested whether melatonin preserves epigenetic modifications in oocytes …

Background DNA methylation is one the epigenetic mechanisms, which is critically involved
in gene expression. This phenomenon is mediated by DNA methyl-transferases and is …

Oxidative stress is known as a major contributing factor involved in oocyte aging, which
negatively affects oocyte quality and development after fertilization. Melatonin is an effective …

Poor‐quality oocytes (those with 1–2 layers of cumulus cells) typically possess low meiotic
competence and development. Prolonging the duration of in vitro maturation (IVM; 52 hr) …

The quality of metaphase II oocytes deteriorates rapidly following ovulation as the result of
an aging process associated with impaired fertilizing potential, disrupted developmental …

After reaching the metaphase II (MII) stage, unfertilised oocytes undergo a time-dependent
process of quality deterioration referred to as oocyte aging. The associated morphological …

Oocyte quality, which is directly related to reprogramming competence, is a major important
limiting factor in animal cloning efficiency. Compared with oocytes matured in vivo, in vitro …

Purpose Studies in bovine and porcine have indicated that melatonin (MT) could induce
meiotic maturation of immature oocytes in vitro. The object of the current study was to …

Melatonin (MLT) is an endogenous hormone with roles in animal germ cell development.
However, the effect of MLT on porcine oocyte maturation and its underlying mechanisms …

Background This study was conducted to investigate effect of exogenous melatonin on the
development of mouse mature oocytes after cryopreservation. Results First, mouse …