Background Regulator of G protein signaling 6 (RGS 6) is an important member of the RGS
family and produces pleiotropic regulatory effects on cardiac pathophysiology. However, the …

Regulator of G-protein signaling 10 (RGS10) is an important member of the RGS family and
produces biological effects in multiple organs. We used a genetic approach to study the role …

In the past 10 years, several publications have highlighted the role of the regulator of G
protein signalling (RGS) family in multiple diseases, including cardiovascular diseases. As …

Regulator of G protein signaling 3 (RGS3) is a negative regulator of G protein‐mediated
signaling. RGS3 has previously been shown to be expressed among various cell types …

Cardiac hypertrophy is a major predictor of heart failure and is regulated by diverse
signaling pathways. As a typical multi-domain member of the regulator of G-protein signaling …

The development of cardiac hypertrophy in response to increased hemodynamic load and
neurohormonal stress is initially a compensatory response that may eventually lead to …

Patel et al RGS10 in Heart Failure 39 was absent in all tissues through development and
adulthood. This technology may increase the feasibility of making new gene knockouts, but it …

Alterations in cardiac G protein-mediated signaling, most prominently G q/11 signaling, are
centrally involved in hypertrophy and heart failure development. Several RGS proteins that …

Regulator of G protein signalling 2 (RGS2) is known to play a protective role in maladaptive
cardiac hypertrophy and heart failure via its ability to inhibit G q-and G s-mediated GPCR …

RGS family members are GTPase-activating proteins (GAPs) for heterotrimeric G proteins.
There is evidence that altered RGS gene expression may contribute to the pathogenesis of …