Abnormal metabolism is a hallmark of cancer cells. Accumulating evidence suggests that
metabolic changes are likely to occur before other cellular responses in cancer cells upon …

Metabolic reprogramming is widely considered a hallmark of cancer, and understanding
metabolic dynamics described by the conversion rates or “fluxes” of metabolites can shed …

Metabolic flux analysis of live cells using NMR enables the study of cancer metabolism and
response to treatment. However, conventional NMR platforms require often prohibitively …

Hyperpolarized [1‐13C] pyruvate can be used to examine the metabolic state of cancer
cells, highlighting a key metabolic characteristic of cancer: the upregulated metabolic flux to …

Hyperpolarized carbon‐13 labeled compounds are increasingly being used in medical MR
imaging (MRI) and MR imaging (MRI) and spectroscopy (MRS) research, due to its ability to …

Hyperpolarized carbon-13 MRI has the advantage of allowing the study of glycolytic flow in
vivo or in vitro dynamically in real-time. The apparent exchange rate constant of a metabolite …

Magnetic resonance (MR)-hyperpolarization based on dynamic nuclear polarization
provides a strongly increased signal intensity allowing real-time metabolic spectroscopic …

Most tumours exhibit a high rate of glycolysis and predominantly produce energy by lactic
acid fermentation. To maintain energy production and prevent toxicity, the lactate generated …

In this study, we describe new methods for studying cancer cell metabolism with
hyperpolarized 13C magnetic resonance spectroscopy (HP 13C MRS) that will enable …

Hyperpolarized 13C magnetic resonance spectroscopy provides a unique opportunity to
detect real-time metabolic fluxes as a means to measure metabolic treatment responses in …