C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay
ES Reis, H Chen, G Sfyroera, PN Monk… - The Journal of …, 2012 - journals.aai.org
The complement anaphylatoxins C3a, C5a, and desarginated C5a (C5a desArg) play critical
roles in the induction of inflammation and the modulation of innate and acquired immune …
roles in the induction of inflammation and the modulation of innate and acquired immune …
C3a (desArg) does not bind to and signal through the human C3a receptor
HC Wilken, O Götze, T Werfel, J Zwirner - Immunology letters, 1999 - Elsevier
Contradictory results have been published in the past regarding the functional responses of
different cell types to the anaphylatoxin C3a and its natural catabolite C3a (desArg). To …
different cell types to the anaphylatoxin C3a and its natural catabolite C3a (desArg). To …
C5L2–an anti-inflammatory molecule or a receptor for acylation stimulating protein (C3a-desArg)?
K Johswich, A Klos - Current topics in innate immunity, 2007 - Springer
Sometimes, two seemingly unrelated research areas suddenly overlap to the surprise of the
scientists involved. This has occurred to the researchers investigating in the complement …
scientists involved. This has occurred to the researchers investigating in the complement …
Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a
B Settmacher, D Bock, H Saad, S Gärtner… - The Journal of …, 1999 - journals.aai.org
The C3a receptor (C3aR) is expressed on most human peripheral blood leukocytes with the
exception of resting lymphocytes, implying a much higher pathophysiological relevance of …
exception of resting lymphocytes, implying a much higher pathophysiological relevance of …
The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses
Q Peng, K Li, SH Sacks, W Zhou - Inflammation & Allergy-Drug …, 2009 - ingentaconnect.com
C3a and C5a, the small (∼ 10KDa) cleavage fragments released by complement activation,
are potent mediators of inflammation. They are anaphylatoxins and act as cell activators with …
are potent mediators of inflammation. They are anaphylatoxins and act as cell activators with …
Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors
CS Colley, B Popovic, S Sridharan, JE Debreczeni… - MAbs, 2018 - Taylor & Francis
ABSTRACT C5a is a potent anaphylatoxin that modulates inflammation through the C5aR1
and C5aR2 receptors. The molecular interactions between C5a–C5aR1 receptor are well …
and C5aR2 receptors. The molecular interactions between C5a–C5aR1 receptor are well …
A sensitive enzyme immunoassay for the quantitation of human C5a/C5a (desArg) anaphylatoxin using a monoclonal antibody with specificity for a neoepitope
M Oppermann, M Schulze, O Götze - Complement and inflammation, 1991 - karger.com
The direct quantitation of C5a/C5a (desArg) in human plasma was achieved by a specific
and highly sensitive ELISA which is based on the neoepitope-specific monoclonal antibody …
and highly sensitive ELISA which is based on the neoepitope-specific monoclonal antibody …
Cloning and characterization of rat C3a receptor: differential expression of rat C3a and C5a receptors by LPS stimulation
Y Fukuoka, JA Ember, TE Hugli - Biochemical and biophysical research …, 1998 - Elsevier
The anaphylatoxin C3a, generated during complement activation, is a factor known to
mediate various inflammatory reactions. The human C3a receptor (C3aR) was recently …
mediate various inflammatory reactions. The human C3a receptor (C3aR) was recently …
[HTML][HTML] Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines
K Johswich, M Martin, J Thalmann… - Journal of Biological …, 2006 - ASBMB
During complement activation the pro-inflammatory anaphylatoxins C3a and C5a are
generated, which interact with the C3a receptor and C5a receptor (CD88), respectively. C5a …
generated, which interact with the C3a receptor and C5a receptor (CD88), respectively. C5a …
Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor
M Farzan, CE Schnitzler, N Vasilieva… - The Journal of …, 2001 - rupress.org
The complement anaphylatoxin C5a and its seven-transmembrane segment (7TMS)
receptor play an important role in host defense and in a number of inflammation-associated …
receptor play an important role in host defense and in a number of inflammation-associated …