[HTML][HTML] Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
Gentamicin causes kidney injury due to its accumulation in proximal tubule epithelial cells
via the megalin/cubilin/CLC-5 complex. Recently, shikonin has been shown to have …
via the megalin/cubilin/CLC-5 complex. Recently, shikonin has been shown to have …
Rutin attenuates gentamicin-induced renal damage by reducing oxidative stress, inflammation, apoptosis, and autophagy in rats
Gentamicin is commonly used against gram-negative microorganisms. Its therapeutic use is
mainly limited by nephrotoxicity. This study was aimed at evaluating the effect of rutin on …
mainly limited by nephrotoxicity. This study was aimed at evaluating the effect of rutin on …
Protective effects of curcumin on acute gentamicin-induced nephrotoxicity in rats
L He, X Peng, J Zhu, G Liu, X Chen… - Canadian Journal of …, 2015 - cdnsciencepub.com
Background: Gentamicin-induced nephrotoxicity is one of the most common causes of acute
kidney injury (AKI). The phenotypic alterations that contribute to acute kidney injury include …
kidney injury (AKI). The phenotypic alterations that contribute to acute kidney injury include …
Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of …
Gentamicin-induced nephrotoxicity has been well documented, although its underlying
mechanisms and preventive strategies remain to be investigated. The present study was …
mechanisms and preventive strategies remain to be investigated. The present study was …
[HTML][HTML] The protective effect of shikonin on renal tubular epithelial cell injury induced by high glucose
Y Tong, J Chuan, L Bai, J Shi, L Zhong, X Duan… - Biomedicine & …, 2018 - Elsevier
Hyperglycemia-induced oxidative stress is thought to play a critical role in the pathogenesis
of diabetic nephropathy (DN). Treating high-glucose (HG)-induced proximal tubule injury …
of diabetic nephropathy (DN). Treating high-glucose (HG)-induced proximal tubule injury …
Protective effects of mirazid on gentamicin-induced nephrotoxicity in rats through antioxidant, anti-inflammatory, JNK1/iNOS, and apoptotic pathways; novel …
Background: As the use of Gentamicin became more widespread, the drug's harmful effects,
particularly nephrotoxicity, became increasingly well-known. Antibacterial and anti …
particularly nephrotoxicity, became increasingly well-known. Antibacterial and anti …
Troxerutin down-regulates KIM-1, modulates p38 MAPK signaling, and enhances renal regenerative capacity in a rat model of gentamycin-induced acute kidney injury
Gentamycin is an aminoglycoside antibiotic that is widely employed for controlling Gram
negative bacterial infections including that caused by the antibiotic-resistant Pseudomonas …
negative bacterial infections including that caused by the antibiotic-resistant Pseudomonas …
Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial …
M Adil, AD Kandhare, G Dalvi, P Ghosh, S Venkata… - Renal failure, 2016 - Taylor & Francis
Background: Gentamicin (GM) is the commonly used antibiotics against Gram-negative
infection, but the nephrotoxic potential of drug limit its clinical interest. The aim of this study …
infection, but the nephrotoxic potential of drug limit its clinical interest. The aim of this study …
Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1
MR Khajevand-Khazaei… - European journal of …, 2018 - Elsevier
Acute kidney injury (AKI) is a common complication following severe sepsis, its incidence is
increasing, and it is associated with a high rate of morbidity and mortality. Rutin is a …
increasing, and it is associated with a high rate of morbidity and mortality. Rutin is a …
Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and …
The aim of this study was to investigate the therapeutic activity of isoquinoline alkaloid
berberine against cisplatin (CP)-induced nephrotoxicity in mice. Berberine was administered …
berberine against cisplatin (CP)-induced nephrotoxicity in mice. Berberine was administered …