Human organoids, self-organized and differentiated from homogenous pluripotent stem cells
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …

The generation of tissue and organs requires close interaction with vasculature from the
earliest moments of embryonic development. Tissue-specific organoids derived from …

The development of vascular networks in microfluidic chips is crucial for the long-term
culture of three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or …

Organoids are biomimetic tissue analogs that are generated via the self‐organization of
stem cells or adult cells relying on developmental biology principles. They present tissue …

Over the last 4 decades, cell culture techniques have evolved towards the creation of in vitro
multicellular entities that incorporate the three-dimensional complexity of in vivo tissues and …

As an emerging research model in vitro, organoids have achieved major progress in
recapitulating morphological aspects of organs and personalized precision therapy. Various …

Understanding mechanisms and manifestations of cardiovascular risk factors, including
diabetes, on vascular cells such as endothelial cells, pericytes, and vascular smooth muscle …

Abstract 3D organoids are widely used as tractable in vitro models capable of elucidating
aspects of human development and disease. However, the manual and low‐throughput …

Organoids derived from human pluripotent stem cells are interesting models to study
mechanisms of morphogenesis and promising platforms for disease modeling and drug …

Blood vessels are fundamental to animal life and have critical roles in many diseases, such
as stroke, myocardial infarction and diabetes. The vasculature is formed by endothelial cells …