The anti-nociceptive activity of naringenin passes through L-arginine/NO/cGMP/KATP channel pathway and opioid receptors

N Moradi, S Fakhri, MH Farzaei… - Behavioural …, 2021 - journals.lww.com
As a promising flavonoid, naringenin has shown potential anti-inflammatory and antioxidant
properties mainly in inflammatory pain models by oral administration. Therefore, we …

Further antinociceptive properties of naringenin on acute and chronic pain in mice

JL Dallazen, CF da Silva, L Hamm… - Natural Product …, 2017 - journals.sagepub.com
Naringenin (NG) is a flavanone abundant in grapefruit and other citrus fruits that presents
several pharmacological effects, such as antioxidant, anti-inflammatory, analgesic, among …

Role of l-arginine/SNAP/NO/cGMP/KATP channel signalling pathway in antinociceptive effect of α-terpineol in mice

S Safaripour, Y Nemati, S Parvardeh… - Journal of Pharmacy …, 2018 - academic.oup.com
Objectives The main purpose of this study was to assess the role of l-arginine/SNAP/NO/
cGMP/KATP channel pathway in analgesic effects of α-terpineol in mice. Methods Male …

Naringenin reduces inflammatory pain in mice

FA Pinho-Ribeiro, AC Zarpelon, V Fattori… - …, 2016 - Elsevier
Naringenin is a flavonoid widely consumed by humans that present anti-inflammatory
activity and low toxicity. Recently, the analgesic effect of naringenin has been demonstrated …

Antinociceptive and anti-inflammatory effect of Naringenin in different nociceptive and inflammatory mice models

N Xue, X Wu, L Wu, L Li, F Wang - Life sciences, 2019 - Elsevier
Inflammation is the vital defensive response triggered by our immune system against an
infection or deleterious stimuli. This response in due course affects its own biological system …

Involvement of the NO/cGMP/KATP pathway in the antinociceptive effect of rosemary (Rosmarinus officinalis) essential oil in mice

V Hajhashemi, M Salimian… - Behavioural …, 2023 - journals.lww.com
Rosemary essential oil (REO) has been used for several medical purposes. Previous
studies have shown the antinociceptive effect of the oil. This study aimed to investigate the …

Therapeutic role of naringenin to alleviate inflammatory pain

MF Manchope, CR Ferraz, SM Borghi… - … , and adverse reactions …, 2022 - Elsevier
Naringenin is a flavonoid from the flavanone class found mainly in citrus fruits. Its flavonoid
structure is responsible for antioxidant activity. Nevertheless, naringenin has a broad range …

The role of l-arginine/NO/cGMP/KATP channel pathway in the local antinociceptive effect of berberine in the rat formalin test

M Rahemi, S Mohtadi, HR Vardanjani… - Behavioural …, 2023 - journals.lww.com
Berberine is an isoquinoline alkaloid naturally produced by several types of plants.
Berberine has extensive pharmacological effects, such as anti-diabetic, anti-inflammatory …

Astaxanthin engages the l-arginine/NO/cGMP/KATP channel signaling pathway toward antinociceptive effects

S Mohammadi, S Fakhri… - Behavioural …, 2021 - journals.lww.com
One of the main functions of the sensory system in our body is to maintain somatosensory
homeostasis. Recent reports have led to a significant advance in our understanding of pain …

[HTML][HTML] Antihyperalgesic properties of honokiol in inflammatory pain models by targeting of NF-κB and Nrf2 signaling

S Khalid, MZ Ullah, AU Khan, R Afridi… - Frontiers in …, 2018 - frontiersin.org
The present study investigates the possible anti-nociceptive effect of intraperitoneal (ip)
honokiol: a phenolic compound originally isolated from Magnolia officinalis, in acute and …