The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex
has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft …

Abstract Cyclin-dependent kinase (CDK)–cyclin complexes require phosphorylation on the
CDK subunit for full activation of their Ser/Thr protein kinase activity. The crystal structure of …

The major events of the cell division cycle are triggered by periodic changes in the activity of
cyclin-dependent protein kinases (CDKs). In mammals, the members of the CDK family …

As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by
extra-and intracellular signals. The activity of cyclin-dependent kinases is controlled by four …

The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the
phosphorylated cyclin A–cyclin-dependent kinase 2 (Cdk2) complex has been determined …

The cyclin D1–cyclin-dependent kinase 4 (CDK4) complex is a key regulator of the transition
through the G1 phase of the cell cycle. Among the cyclin/CDKs, CDK4 and cyclin D1 are the …

The crystal structure of the cyclin D-dependent kinase Cdk6 bound to the p19INK4d protein
has been determined at 1.9 Å resolution. The results provide the first structural information …

We have prepared phosphorylated cyclin-dependent protein kinase 2 (CDK2) for
crystallization using the CDK-activating kinase 1 (CAK1) fromSaccharomyces cerevisiae …

Progression through the eukaryotic cell cycle is driven by the orderly activation of cyclin-
dependent kinases (CDKs). For activity, CDKs require association with a cyclin and …

The division cycle of eukaryotic cells is regulated by a family of protein kinases known as the
cyclin-dependent kinases (CDKs) 1, 2. The sequential activation of individual members of …