An ER‐targeting iridium (III) complex that induces immunogenic cell death in non‐small‐cell lung cancer
L Wang, R Guan, L Xie, X Liao, K Xiong… - Angewandte …, 2021 - Wiley Online Library
Immunogenic cell death (ICD) is a vital component of therapeutically induced anti‐tumor
immunity. An iridium (III) complex (Ir1), containing an N, N‐bis (2‐chloroethyl)‐azane …
immunity. An iridium (III) complex (Ir1), containing an N, N‐bis (2‐chloroethyl)‐azane …
Iridium (III) complexes targeting apoptotic cell death in cancer cells
DL Ma, C Wu, KJ Wu, CH Leung - Molecules, 2019 - mdpi.com
Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years,
non-platinum-based scaffolds have been exploited as viable candidates for the exploitation …
non-platinum-based scaffolds have been exploited as viable candidates for the exploitation …
PlatinER: A highly potent anticancer platinum (II) complex that induces endoplasmic reticulum stress driven immunogenic cell death
Immunogenic cell death (ICD) is a rare immunostimulatory form of cell death that can
improve the clinical outcomes of chemo‐immunotherapeutic combination regimens through …
improve the clinical outcomes of chemo‐immunotherapeutic combination regimens through …
Current status of iridium-based complexes against lung cancer
T Yang, M Zhu, M Jiang, F Yang, Z Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
Lung cancer is one of the most common malignant tumors, with the highest mortality rate in
the world, and its incidence is second only to breast cancer. It has posed a serious threat to …
the world, and its incidence is second only to breast cancer. It has posed a serious threat to …
Target profiling of an iridium (III)-based immunogenic cell death inducer unveils the engagement of unfolded protein response regulator BiP
Clinical chemotherapeutic drugs have occasionally been observed to induce antitumor
immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic …
immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic …
A photoactivated Ir (iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of …
G Vigueras, L Markova, V Novohradsky… - Inorganic Chemistry …, 2021 - pubs.rsc.org
Several anticancer chemotherapies, while eliminating the bulk of tumor cells, often fail, as
they do not obliterate a small fraction of malignant cancer stem cells (CSCs). Thus …
they do not obliterate a small fraction of malignant cancer stem cells (CSCs). Thus …
First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro
D Wernitznig, K Kiakos, G Del Favero, N Harrer… - Metallomics, 2019 - academic.oup.com
The ruthenium complex sodium trans-[tetrachloridobis (1 H-indazole) ruthenate
(iii)](KP1339/IT-139) showed preclinical activity in a variety of in vivo tumor models including …
(iii)](KP1339/IT-139) showed preclinical activity in a variety of in vivo tumor models including …
Augmenting Cancer Therapy with a Supramolecular Immunogenic Cell Death Inducer: A Lysosome-Targeted NIR-Light-Activated Ruthenium (II) Metallacycle
Though immunogenic cell death (ICD) has garnered significant attention in the realm of
anticancer therapies, effectively stimulating strong immune responses with minimal side …
anticancer therapies, effectively stimulating strong immune responses with minimal side …
A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex
V Novohradsky, L Zerzankova, J Stepankova… - Metallomics, 2014 - academic.oup.com
The cellular mechanism of action of an iridium (iii) half-sandwich complex [(η5-
C5Me4C6H4C6H5) Ir (phen) Cl] PF6 (phen= phenanthroline)(1) is reported. Complex 1 was …
C5Me4C6H4C6H5) Ir (phen) Cl] PF6 (phen= phenanthroline)(1) is reported. Complex 1 was …
Ferroptosis photoinduced by new cyclometalated iridium (III) complexes and its synergism with apoptosis in tumor cell inhibition
Limited therapeutic efficacy to hypoxic and refractory solid tumors has hindered the practical
application of photodynamic therapy (PDT). Two new benzothiophenylisoquinoline (btiq) …
application of photodynamic therapy (PDT). Two new benzothiophenylisoquinoline (btiq) …