Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles
Efforts to determine why new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) variants demonstrate improved fitness have been limited to analyzing mutations in the …
2) variants demonstrate improved fitness have been limited to analyzing mutations in the …
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant
contains extensive sequence changes relative to the earlier-arising B. 1, B. 1.1, and Delta …
contains extensive sequence changes relative to the earlier-arising B. 1, B. 1.1, and Delta …
The emerging plasticity of SARS-CoV-2
KD McCormick, JL Jacobs, JW Mellors - Science, 2021 - science.org
Viruses evolve as a result of mutation (misincorporations, insertions or deletions, and
recombination) and natural selection for favorable traits such as more efficient viral …
recombination) and natural selection for favorable traits such as more efficient viral …
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
The spike aspartic acid–614 to glycine (D614G) substitution is prevalent in global severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral …
The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types
Recently, a novel isolate of the SARS-CoV-2 virus carrying a point mutation in the Spike
protein (D614G) has emerged and rapidly surpassed others in prevalence, including the …
protein (D614G) has emerged and rapidly surpassed others in prevalence, including the …
Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness
Repeated emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants with increased fitness underscores the value of rapid detection and characterization …
variants with increased fitness underscores the value of rapid detection and characterization …
Sequential intrahost evolution and onward transmission of SARS-CoV-2 variants
AS Gonzalez-Reiche, H Alshammary… - Nature …, 2023 - nature.com
Persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have
been reported in immune-compromised individuals and people undergoing immune …
been reported in immune-compromised individuals and people undergoing immune …
Mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America
The importance of understanding SARS-CoV-2 evolution cannot be overlooked. Recent
studies confirm that natural selection is the dominating mechanism of SARS-CoV-2 …
studies confirm that natural selection is the dominating mechanism of SARS-CoV-2 …
Development of a single-cycle infectious SARS-CoV-2 virus replicon particle system for use in biosafety level 2 laboratories
J Malicoat, S Manivasagam, S Zuñiga, I Sola… - Journal of …, 2022 - Am Soc Microbiol
Research activities with infectious severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) are currently permitted only under biosafety level 3 (BSL3) containment. Here, we …
CoV-2) are currently permitted only under biosafety level 3 (BSL3) containment. Here, we …
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally.
We therefore compare the properties of the mutated S protein (SG614) with the original …
We therefore compare the properties of the mutated S protein (SG614) with the original …
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