Cyanine dyes are exceptionally useful probes for a range of fluorescence‐based
applications, but their photon output can be limited by trans‐to‐cis photoisomerization. We …

Conspectus Optical approaches that visualize and manipulate biological processes have
transformed modern biomedical research. An enduring challenge is to translate these …

Far-red cyanine fluorophores find extensive use in modern microscopy despite modest
quantum yields. To improve the photon output of these molecules, we report a synthetic …

The near‐infrared window of fluorescent heptamethine cyanine dyes greatly facilitates
biological imaging because there is deep penetration of the light and negligible background …

Heptamethine cyanines are favorable for fluorescence imaging applications in biological
systems owing to their near-infrared (NIR) absorption and emission. However, it is very …

Heptamethine cyanine dyes enable deep tissue fluorescence imaging in the near infrared
(NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested …

Appending conformationally restraining ring systems to the cyanine chromophore creates
exceptionally bright fluorophores in the visible range. Here, we report the application of this …

Cyanine dyes are well-known for their bright fluorescence and utility in biological imaging.
However, cyanines also readily photoisomerize to produce nonemissive dark states. Co …

Maleimide-cysteine chemistry has been a routine practice for the site-specific labeling of
fluorophores to proteins since the 1950s. This approach, however, cannot bring out the best …

Heptamethine indocyanines are invaluable probes for near-infrared (NIR) imaging. Despite
broad use, there are only a few synthetic methods to assemble these molecules, and each …