ABSTRACT Reduced oxygen (O2) levels (hypoxia) are present during embryogenesis and
exposure to altitude and in pathologic conditions. During embryogenesis, myogenic …

In skeletal muscle tissue, oxygen (O2) plays a pivotal role in both metabolism and the
regulation of several intercellular pathways, which can modify proliferation, differentiation …

Skeletal muscle stem/progenitor cells, which give rise to terminally differentiated muscle,
represent potential therapies for skeletal muscle diseases. Delineating the factors regulating …

Facial paralysis is a physically, psychologically, and socially disabling condition. Innovative
treatment strategies based on regenerative medicine, in particular tissue engineering of …

Microenvironmental oxygen (O2) regulates stem cell activity, and a hypoxic niche with low
oxygen levels has been reported in multiple stem cell types. Satellite cells are muscle …

The microenvironment of the injury site can have profound effects on wound healing. Muscle
injury results in ischemia leading to short‐term local hypoxia, but there are conflicting reports …

Hypoxia alters the biological functions of skeletal muscle cells to proliferate and differentiate
into myotubes. However, the cellular responses of myoblasts to hypoxia differ according to …

Major problems in stem cell biology revolve around defining the developmental potential of
cell populations and understanding how their potential is maintained or progressively …

The remarkable regeneration capability of skeletal muscle depends on the coordinated
proliferation and differentiation of satellite cells (SCs). The self-renewal of SCs is critical for …

The physiological oxygen concentration of many tissues is far lower than that in which cells
are typically cultured in vitro and this may inadvertently influence the proliferation and …