Chrysin loaded nanovesicles ameliorated diabetic peripheral neuropathy. Role of NGF/AKT/GSK-3β pathway

SA El-Marasy, MM AbouSamra… - Chemico-Biological …, 2023 - Elsevier
Diabetic peripheral neuropathy (DPN) is a common diabetic complication. Chrysin (CHY)
has many biological properties but poor oral bioavailability. This study investigates the effect …

[HTML][HTML] Isolation, characterization, development and evaluation of phytoconstituent based formulation for diabetic neuropathy

R Pathak, N Sachan, A Kabra, AS Alanazi… - Saudi Pharmaceutical …, 2023 - Elsevier
Abstract Background Morus alba Linn, referred to as white mulberry, is a potential traditional
medicine for diabetes and neuroprotection. Aim Isolation, characterization, development and …

Chrysin nanocapsules with dual anti-glycemic and anti-hyperlipidemic effects: Chemometric optimization, physicochemical characterization and pharmacodynamic …

D El-Hussien, GM El-Zaafarany, M Nasr… - International Journal of …, 2021 - Elsevier
Chrysin is a flavonoid with various biological and therapeutic properties. However, its poor
oral bioavailability and solubility are challenging barriers against its therapeutic use, which …

Compound Qiying Granules alleviates diabetic peripheral neuropathy by inhibiting endoplasmic reticulum stress and apoptosis

Y Hu, C Chen, Z Liang, T Liu, X Hu, G Wang, J Hu… - Molecular …, 2023 - Springer
Background Diabetic peripheral neuropathy (DPN) is a major complication of diabetes. This
study aimed to investigate the therapeutic effects and molecular mechanisms of Compound …

Tannic acid coated nanosuspension for oral delivery of chrysin intended for anti-schizophrenic effect in mice

A Salama, AH Salama, MH Asfour - International Journal of Pharmaceutics, 2024 - Elsevier
Chrysin is a flavonoid drug with numerous therapeutic activities. It suffers from low intestinal
absorption owing to its hydrophobicity. Therefore, the aim of this study is to exploit the …

Chrysin attenuates high glucose-induced BMSC dysfunction via the activation of the PI3K/AKT/Nrf2 signaling pathway

Y Li, X Wang - Drug Design, Development and Therapy, 2022 - Taylor & Francis
Purpose High glucose environment in diabetes mellitus induces the dysfunction of bone
marrow-derived mesenchymal stromal cells (BMSCs) and impairs bone regeneration …

Enhanced dissolution and antioxidant activity of chrysin nanoparticles employing co-precipitation as a technique

H Kaur, D Singh Malik, G Kaur - Pharmaceutical …, 2015 - ingentaconnect.com
Background: Polyphenols are promising drug candidates because of their multifaceted
properties such as anti-cancer, anti-diabetic, anti-oxidant, etc. However, their potential has …

Combinatory effect and modes of action of chrysin and bone marrow-derived mesenchymal stem cells on streptozotocin/nicotinamide-induced diabetic rats

HM Sayed, AS Awaad, FEZS Abdel Rahman… - Pharmaceuticals, 2022 - mdpi.com
The purpose of this study was to see how chrysin and/or bone marrow-derived
mesenchymal stem cells (BM-MSCs) affected streptozotocin (STZ)/nicotinamide (NA) …

Combination of quercetin, hirudin and cinnamaldehyde promotes schwann cell differentiation and myelination against high glucose by inhibiting ERK signaling …

D Liu, X Liang, Y Sun, Y Wu, H Zhang - Chinese journal of integrative …, 2020 - Springer
Objective To investigate the therapeutic and synergistic effects of QHC (combination of
quercetin (Q), hirudin (H) and cinnamaldehyd (C)) on Schwann cell differentiation and …

Design and optimization of crocetin loaded PLGA nanoparticles against diabetic nephropathy via suppression of inflammatory biomarkers: a formulation approach to …

X Yang - Drug Delivery, 2019 - Taylor & Francis
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus whose expand
process is linked with the fibrosis, renal hypertrophy and inflammation. The current study …