Current clinical strategies for restoring cartilage defects do not adequately consider taking
the necessary steps to prevent the formation of hypertrophic tissue at injury sites …

Articular cartilage shows limited self-healing ability owing to its low cellularity and
avascularity. Untreated cartilage defects display an increased propensity to degenerate …

Due to a blood supply shortage, articular cartilage has a limited capacity for self-healing
once damaged. Articular chondrocytes, cartilage progenitor cells, embryonic stem cells, and …

The outcome of cartilage repair techniques is often hampered by unwanted ossification (eg
intralesional osteophytes) at the site of the repaired cartilage. Furthermore, stimulating …

Osteoarthritis (OA) is a chronic degenerative disease that affects the whole joint, especially
the knee joint. Its main features include articular cartilage defects and osteophyte formation …

Osteoarthritis (OA) is an extremely prevalent age-related condition. The economic and
societal burden due to the cost of symptomatic treatment, inability to work, joint replacement …

In the cartilage matrix, complex interactions occur between angiogenic and anti-angiogenic
components, growth factors, and environmental stressors to maintain a proper cartilage …

Successful recapitulation of the anatomical microarchitecture and biomechanics of the
native articular cartilage under in vitro culture conditions is still an elusive topic of research …

Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …

Hypertrophy is a key component of endochondral ossification, the process controlling
skeletal (cartilage, bone) development by differentiation of mesenchymal stem cells …