Lysosomal-dependent self-degradative (autophagic) mechanisms are essential for the
maintenance of normal homeostasis in all eukaryotic cells. Several types of such self …

Autophagy is an evolutionarily-conserved process that delivers diverse cytoplasmic
components to the lysosomal compartment for either recycling or degradation. This involves …

The ubiquitin proteasome system (UPS) and macroautophagy (hereafter called autophagy)
were, for a long time, regarded as independent degradative pathways with few or no points …

Autophagy is an evolutionarily conserved intracellular catabolic process that delivers
cytoplasmic components to lysosomes for degradation and recycling. Although originally …

Autophagy, an efficient and effective approach to clear rapidly damaged organelles,
macromolecules, and other harmful cellular components, enables the recycling of nutrient …

The living cell is an ever changing, responsive, and adaptive environment where proteins
play key roles in all processes and functions. While the scientific community focused for a …

Proteolysis in eukaryotic cells is mainly mediated by the ubiquitin (Ub)-proteasome system
(UPS) and the autophagylysosome system (hereafter autophagy). The UPS is a selective …

The ubiquitin-proteasome pathway (UPP) and autophagy play integral roles in cellular
homeostasis. As part of their normal life cycle, most proteins undergo ubiquitination for some …

The two main protein degradation systems of eukaryotic cells, the ubiquitin-proteasome
system and autophagy, have been thought of as quite separate systems. However, recent …

Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade
cellular constituents and is often induced under cellular stress conditions to restore cell …