Acoustic cell assembly devices are applied in cell spheroid fabrication attributed to their
rapid, label-free and low-cell damage production of size-uniform spheroids. However, the …

Multicellular spheroids represent a promising approach to mimic 3D tissues in vivo for
emerging applications in regenerative medicine, therapeutic screening, and drug discovery …

Precise and flexible three-dimensional (3D) cell construct assembly using external forces or
fields can produce micro-scale cellular architectures with intercellular connections, which is …

3D cell cultures such as cell spheroids are widely used for tissue engineering, regenerative
medicine, and translational medicine, but challenges remain in recapitulating the …

There is a rapidly growing interest in generation of 3D organotypic microtissues with human
physiologically relevant structure, function, and cell population in a wide range of …

Three-dimensional (3D) cell arrays provide an in vitro platform for clinical drug screening,
but the bulky culture devices limit their application scenarios. Here, we demonstrate an …

Three-dimensional cell agglomerates are broadly useful in tissue engineering and drug
testing. We report a well-free method to form large (1.4-mm) multicellular clusters using 100 …

The multicellular spheroid is an important 3D cell culture model for drug screening, tissue
engineering, and fundamental biological research. Although several spheroid formation …

Many tissues in the human body are composed of densely-packed cells and minimal
extracellular matrix (ECM). The resulting close cell proximity is important to retain cell …

Abstract 3D cell spheroid culture has emerged as a more faithful recreation of cell growth
environment compared to conventional 2D culture, as it can maintain tissue structures …