Most cancers are diagnosed in persons over the age of sixty, but little is known about how
age impacts tumorigenesis. While aging is accompanied by mutation accumulation-widely …

Lung cancer is primarily a disease of the elderly. Despite shared molecular changes
between aging and cancer—such as permissive chromatin states and deregulated protein …

In the context of tumorigenesis, cellular senescence has both beneficial and detrimental
roles. Although the essentially irreversible cell cycle arrest mechanism can prevent the …

Older age is a strong risk factor for several diseases, including cancer. The etiology and
biology of age-associated differences among cancers are poorly understood. To address …

Introduction: Cellular senescence (CS) is a crucial anticancer mechanism that is defined by
irreversible cell-cycle arrest and senescence-associated secretory phenotype (SASP). CS …

Aging is the major determinant of cancer incidence, which, in turn, is likely dictated in large
part by processes that influence the progression of early subclinical (occult) cancers …

Ageing can be broadly described as a progressive decline in physiological functions,
leading to increased susceptibility to diseases and mortality. Ageing is the most important …

Cancer is an age-related disease, as incidence and mortality for most types of cancer
increase with age. However, how molecular alterations in tumors differ among patients of …

Recent advances in our understanding of the molecular and cellular signaling pathways that
drive aging have revealed several genetic and environmental manipulations that can …

Aging is the primary risk factor for many individual cancer types, including lung
adenocarcinoma (LUAD). To understand how aging-related alterations in the regulation of …