There is a high need to improve the assessment of, especially non-genotoxic, carcinogenic
features of chemicals. We therefore explored a toxicogenomics-based approach using …

The well-defined battery of in vitro systems applied within chemical cancer risk assessment
is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict …

In the area of omics profiling in toxicology, ie toxicogenomics, characteristic molecular
profiles have previously been incorporated into prediction models for early assessment of a …

Evaluating the risk of chemical carcinogenesis has long been a challenge owing to the
protracted nature of the pathology and the limited translatability of animal models. Although …

The long‐term rodent bioassay is the standard method to predict the carcinogenic hazard of
chemicals for humans. However, this assay is costly, and the results take at least two years …

The current strategy for identifying the carcinogenicity of drugs involves the 2-year bioassay
in male and female rats and mice. As this assay is cost-intensive and time-consuming there …

Non-genotoxic carcinogens are substances that induce tumorigenesis by non-mutagenic
mechanisms and long term rodent bioassays are required to identify them. Recent studies …

Long-term rodent carcinogenicity studies for evaluation of chemicals and pharmaceuticals
concerning their carcinogenic potential to humans are currently receiving critical revision …

The current gold-standard method for cancer safety assessment of drugs is a rodent two-
year bioassay, which is associated with significant costs and requires testing a high number …

Toxicogenomics technology defines toxicity gene expression signatures for early predictions
and hypotheses generation for mechanistic studies, which are important approaches for …