Association between immune-related side effects and efficacy and benefit of immune checkpoint inhibitors–a systematic review and meta-analysis

S Hussaini, R Chehade, RG Boldt, J Raphael… - Cancer Treatment …, 2021 - Elsevier
Background The use of immune checkpoint inhibitors (ICIs) has become standard therapy in
many tumor sites. The aim of this study is to systematically review the literature to determine …

Are immune-related adverse events associated with the efficacy of immune checkpoint inhibitors in patients with cancer? A systematic review and meta-analysis

X Zhou, Z Yao, H Yang, N Liang, X Zhang, F Zhang - BMC medicine, 2020 - Springer
Background A number of studies have reported an association between the occurrence of
immune-related adverse events (irAEs) and clinical efficacy in patients undergoing treatment …

[HTML][HTML] Immune-related adverse events as potential surrogates of immune checkpoint inhibitors' efficacy: a systematic review and meta-analysis of randomized …

V Amoroso, F Gallo, A Alberti, D Paloschi, WF Bravo… - ESMO open, 2023 - Elsevier
Background Immune-related adverse events (irAEs) are frequently reported during immune
checkpoint inhibitor (ICI) therapy and are associated with long-term outcomes. It is unknown …

Immune-related adverse events and survival in solid tumors treated with immune checkpoint inhibitors: a systematic review and meta-analysis

F Petrelli, G Grizzi, M Ghidini, A Ghidini… - Journal of …, 2020 - journals.lww.com
Immune-related adverse events (irAEs) are autoimmune-toxic effects associated with
immune checkpoint inhibitors (ICIs) used for the treatment of advanced solid tumors. We …

Not all immune-checkpoint inhibitors are created equal: meta-analysis and systematic review of immune-related adverse events in cancer trials

B El Osta, F Hu, R Sadek, R Chintalapally… - Critical reviews in …, 2017 - Elsevier
Background Targeting immune checkpoints is a novel approach in cancer therapy. This
strategy may trigger immune related adverse events (irAE). We hypothesize that the …

A systematic review of adverse events in randomized trials assessing immune checkpoint inhibitors

P Arnaud‐Coffin, D Maillet, HK Gan… - … journal of cancer, 2019 - Wiley Online Library
The advent of immune checkpoint‐inhibitors (CPI) has transformed treatment for several
cancer types. This review was performed to assess the rate of adverse events (AEs) …

Association of immune related adverse events with efficacy of immune checkpoint inhibitors and overall survival in cancers: a systemic review and meta-analysis

Y Fan, W Xie, H Huang, Y Wang, G Li, Y Geng… - Frontiers in …, 2021 - frontiersin.org
Objectives Immune checkpoint inhibitors (ICIs) have brought impressive benefits to cancer
patients, however often accompanied with immune-related adverse events (irAEs). We …

Immune-related adverse events: promising predictors for efficacy of immune checkpoint inhibitors

L Zhong, Q Wu, F Chen, J Liu, X Xie - Cancer Immunology …, 2021 - Springer
Purpose This study was designed to investigate the correlation between immune-related
adverse events (irAEs) of immune checkpoint inhibitors (ICIs) and corresponding efficacy …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events

JR Brahmer, H Abu-Sbeih, PA Ascierto… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several
cancers. While these immunotherapies have improved patient outcomes in many clinical …

Treatment-related adverse events of combination immune checkpoint inhibitors: systematic review and meta-analysis

R Park, L Lopes, CR Cristancho, IM Riano… - Frontiers in …, 2020 - frontiersin.org
Background: Although clinical practice guidelines for the management of Immune
Checkpoint Inhibitor (ICI)-related adverse events have recently been published, precise and …