Abstract Thyroid-stimulating hormone (TSH), through activation of its G-protein-coupled
thyrotropin receptor (TSHR), controls the synthesis of thyroid hormone—an essential …

Thyroid hormones are vital in metabolism, growth and development. Thyroid hormone
synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR). In …

Objective: To analyze interactions between the thyroid-stimulating hormone receptor (TSHR)
and a thyroid-stimulating human monoclonal autoantibody (M22) at the molecular level …

TSH binding to the TSH receptor (TSHR) induces thyrocyte growth and proliferation primarily
by activating the adenylyl cyclase signaling pathway. Relative to the other glycoprotein …

The discovery of thyroid-stimulating autoantibodies by Adams and Purves 50 years ago was
one of the most important observations in the history of thyroidology. Since that time, the …

The availability of human monoclonal antibodies (MAbs) to the TSHR has enabled major
advances in our understanding of how TSHR autoantibodies interact with the receptor …

The application of molecular biology to the study of the thyrotropin receptor (TSHR) has led
to major advances in our understanding of its structure, function, and relationship to the …

The thyroid-stimulating hormone receptor (TSHR) has a central role in thyrocyte function and
is also one of the major autoantigens for the autoimmune thyroid diseases. We review the …

A complex of the TSH receptor extracellular domain (amino acids 22–260; TSHR260) bound
to a blocking-type human monoclonal autoantibody (K1-70) was purified, crystallised and …

TSH receptor (TSHR) autoantibodies (TRAbs) play a key role in the pathogenesis of Graves'
disease. In the majority of patients, TRAbs stimulate thyroid hormone synthesis via activation …