[HTML][HTML] Karyotypic stasis and swarming influenced the evolution of viral tolerance in a species-rich bat radiation

NM Foley, AJ Harris, KR Bredemeyer, M Ruedi… - Cell Genomics, 2024 - cell.com
The emergence of COVID-19 and severe acute respiratory syndrome (SARS) has prioritized
understanding bats' viral tolerance. Myotis bats are exceptionally species rich and have …

[HTML][HTML] Reference-quality bat genomes illuminate adaptations to viral tolerance and disease resistance

M Hiller, A Morales, A Ahmed, L Hilgers, B Kirilenko… - 2023 - europepmc.org
Bats carry viruses that can cause severe disease in other mammals. Asymptomatic
infections in bats suggest limited tissue-damaging inflammation and immunopathology. To …

Comparative analysis of bat genomes provides insight into the evolution of flight and immunity

G Zhang, C Cowled, Z Shi, Z Huang, KA Bishop-Lilly… - Science, 2013 - science.org
Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for
some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and …

MHC class II genes mediate susceptibility and resistance to coronavirus infections in bats

DW Schmid, M Meyer, K Wilhelm, T Tilley… - Molecular …, 2023 - Wiley Online Library
Understanding the immunogenetic basis of coronavirus (CoV) susceptibility in major
pathogen reservoirs, such as bats, is central to inferring their zoonotic potential. Members of …

[HTML][HTML] The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2

JE Pekar, S Lytras, M Ghafari, AF Magee, E Parker… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The emergence of SARS-CoV in 2002 and SARS-CoV-2 in 2019 has led to increased
sampling of related sarbecoviruses circulating primarily in horseshoe bats. These viruses …

[HTML][HTML] Immunological features of bats: resistance and tolerance to emerging viruses

WL Demian, O Cormier, K Mossman - Trends in Immunology, 2024 - cell.com
Bats are among the most diverse mammalian species, representing over 20% of mammalian
diversity. The past two decades have witnessed a disproportionate spillover of viruses from …

[HTML][HTML] Next generation sequencing revolutionizes organismal biology research in bats

KM Garg, V Lamba, A Sanyal, P Dovih… - Journal of Molecular …, 2023 - Springer
The advent of next generation sequencing technologies (NGS) has greatly accelerated our
understanding of critical aspects of organismal biology from non-model organisms. Bats …

Evidence of significant natural selection in the evolution of SARS-CoV-2 in bats, not humans

OA MacLean, S Lytras, JB Singer… - COVID-19 …, 2020 - scholarshare.temple.edu
RNA viruses are proficient at switching to novel host species due to their fast mutation rates.
Implicit in this assumption is the need to evolve adaptations in the new host species to …

Targeted genomic sequencing with probe capture for discovery and surveillance of coronaviruses in bats

KS Kuchinski, KD Loos, DM Suchan, JN Russell… - Elife, 2022 - elifesciences.org
Public health emergencies like SARS, MERS, and COVID-19 have prioritized surveillance of
zoonotic coronaviruses, resulting in extensive genomic characterization of coronavirus …

[HTML][HTML] Evolutionary signatures governing the codon usage bias in coronaviruses and their implications for viruses infecting various bat species

N Kumar, R Kaushik, C Tennakoon, VN Uversky… - Viruses, 2021 - mdpi.com
Many viruses that cause serious diseases in humans and animals, including the
betacoronaviruses (beta-CoVs), such as SARS-CoV, MERS-CoV, and the recently identified …