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Introduction: Desired clinical outcome of pharmacotherapy of brain diseases largely …

The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …

The blood–brain barrier (BBB) is a highly regulated and efficient barrier that provides a
sanctuary to the brain. It is designed to regulate brain homeostasis and to permit selective …

Methods Essential information on BBB cellular microenvironment were reviewed and
discussed towards impacts of BBB on brain drug delivery and targeting. Results Brain …

Due to the physiological and structural properties of the blood–brain barrier (BBB), the
delivery of drugs to the brain poses a unique challenge in patients with central nervous …

The integrity of the blood–brain barrier (BBB) is essential for normal central nervous system
(CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the …

The blood–brain barrier (BBB) denies many therapeutic agents access to brain tumours and
other diseases of the central nervous system (CNS). Despite remarkable advances in our …

1. Many neurodegenerative diseases, cancer and infections of the brain become more
prevalent as populations become older. Despite major advances in neuroscience, the blood …

The blood-brain barrier (BBB) is formed by the brain capillary endothelium and excludes
from the brain∼ 100% of large-molecule neurotherapeutics and more than 98% of all small …

The development of new drugs for the brain has not kept pace with progress in the
molecular neurosciences, because the majority of new drugs discovered do not cross the …