The stem cell factor-stimulated melanogenesis in human melanocytes can be abrogated by interrupting the phosphorylation of MSK1: evidence for involvement of the …

T Niwano, S Terazawa, H Nakajima… - Archives of …, 2018 - Springer
We recently found that treatment of normal human melanocytes (NHMs) with the antioxidant
astaxanthin (AX) suppresses the stem cell factor (SCF)-stimulated protein expression levels …

Abrogating effect of a xanthophyll carotenoid astaxanthin on the stem cell factor-induced stimulation of human epidermal pigmentation

H Nakajima, K Fukazawa, Y Wakabayashi… - Archives of …, 2012 - Springer
We established a model for the stem cell factor (SCF)-associated stimulation of human
epidermal equivalent (HEE) pigmentation. The addition of SCF (at 5 nM) gradually …

Withaferin A abolishes the stem cell factor-stimulated pigmentation of human epidermal equivalents by interrupting the auto-phosphorylation of c-KIT in human …

S Terazawa, H Nakajima, K Fukasawa… - Archives of …, 2015 - Springer
We characterized the mechanism (s) underlying the abrogating effect of withaferin A (WFA)
on the stem cell factor (SCF)-stimulated pigmentation of human epidermal equivalents …

[HTML][HTML] The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis

JM Grichnik, JA Burch, J Burchette, CR Shea - Journal of Investigative …, 1998 - Elsevier
During development, the interaction of stem cell factor (SCF) with its receptor, KIT, is critical
for the survival of melanocytes. Limited in vivo human studies have suggested a possible …

Signaling cascades activated by UVB in human melanocytes lead to the increased expression of melanocyte receptors, endothelin B receptor and c‐KIT

S Terazawa, G Imokawa - Photochemistry and Photobiology, 2018 - Wiley Online Library
A single exposure of normal human melanocytes (NHM s) to ultraviolet B (UVB) radiation
induces a distinct increase in the expression of c‐KIT and endothelin B receptor (EDNRB) …

Glucosamine abrogates the stem cell factor+ endothelin-1-induced stimulation of melanogenesis via a deficiency in MITF expression due to the proteolytic …

T Niwano, S Terazawa, Y Sato, T Kato… - Archives of …, 2018 - Springer
We have already reported that glucosamine (GlcN) distinctly abrogates the pigmentation of
human epidermal equivalents stimulated by stem cell factor+ endothelin-1 (SE). In this study …

[HTML][HTML] The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced pigmentation

A Hachiya, A Kobayashi, A Ohuchi, Y Takema… - Journal of Investigative …, 2001 - Elsevier
The interaction of stem cell factor with its receptor, c-kit, is well known to be critical to the
survival of melanocytes. Little is known about the role (s) of the stem cell factor/c-kit …

[HTML][HTML] Production of the soluble form of KIT, s-KIT, abolishes stem cell factor-induced melanogenesis in human melanocytes

S Kasamatsu, A Hachiya, K Higuchi, A Ohuchi… - Journal of investigative …, 2008 - Elsevier
The signaling of stem cell factor (SCF) and its receptor KIT (membrane-bound KIT; m-KIT)
plays an important role in melanocyte development, survival, proliferation, and …

Stem cell factor induces ERM proteins phosphorylation through PI3K activation to mediate melanocyte proliferation and migration

S Jeon, NH Kim, JY Kim, AY Lee - Pigment cell & melanoma …, 2009 - Wiley Online Library
Stem cell factor (SCF) activates a variety of signals associated with stimulation of
proliferation, differentiation, migration, and survival in melanocytes. However, the molecular …

[HTML][HTML] Bcl-2 reduced and fas activated by the inhibition of stem cell factor/KIT signaling in murine melanocyte precursors

S Kimura, T Kawakami, Y Kawa, Y Soma… - Journal of investigative …, 2005 - Elsevier
Stem cell factor (SCF) and its receptor, KIT, are essential to the migration and differentiation
of melanocytes during embryogenesis. We previously demonstrated that apoptosis is …