Meteorin-like protein (METRNL)/IL-41 improves LPS-induced inflammatory responses via AMPK or PPARδ–mediated signaling pathways

TW Jung, DH Pyun, TJ Kim, HJ Lee, ES Park… - Advances in Medical …, 2021 - Elsevier
Purpose Meteorin-like protein (METRNL)(also known as IL-41), recently identified as a
myokine, is released in response to muscle contraction. It improves the skeletal muscle …

[HTML][HTML] Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K/Akt/NF-κB and NLRP3/caspase …

J Liu, S Jia, Y Yang, L Piao, Z Wang, Z Jin… - Biomedicine & …, 2023 - Elsevier
The production of metrnl, a novel adipomyokine, is induced upon exercise in adipose tissue
and skeletal muscle. In this study, we investigated the anti-inflammatory and antipyroptotic …

[HTML][HTML] Meteorin-like (METRNL) attenuates myocardial ischemia/reperfusion injury-induced cardiomyocytes apoptosis by alleviating endoplasmic reticulum stress via …

L Xu, Y Cai, Y Wang, C Xu - Medical Science Monitor: International …, 2020 - ncbi.nlm.nih.gov
Background Myocardial ischemia mediates the progression of multiple cardiovascular
diseases and leads to serious damage to the morphology, function, and metabolism of …

Meteorin-like/Meteorin-β protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway

Z Chen, J Li, H Peng, M Zhang, X Wu, F Gui, W Li… - Molecular …, 2023 - Springer
Background Ferroptosis plays an essential role in lipopolysaccharide (LPS)-induced acute
lung injury (ALI). Meteorin-like/Meteorin-β (Metrnβ) is a protein secreted by skeletal muscle …

LPS promotes the progression of sepsis by activation of lncRNA HULC/miR-204-5p/TRPM7 network in HUVECs

X Chen, D Song - Bioscience Reports, 2020 - portlandpress.com
Sepsis is a systemic inflammatory response syndrome caused by infection.
Lipopolysaccharide (LPS) has been reported to induce inflammatory responses, and long …

Metrnl deficiency retards skin wound healing in mice by inhibiting AKT/eNOS signaling and angiogenesis

T Xu, S Qing, J Zhao, J Song, Z Miao, J Li… - Acta Pharmacologica …, 2023 - nature.com
Meteorin-like (Metrnl) is a novel secreted protein with various biological activities. In this
study, we investigated whether and how Metrnl regulated skin wound healing in mice …

Liquiritin reduces lipopolysaccharide-aroused HaCaT cell inflammation damage via regulation of microRNA-31/MyD88

X Yang, X Dang, X Zhang, S Zhao - International immunopharmacology, 2021 - Elsevier
Background Pressure ulcers are a common issue for people who have limited mobility. This
study tested the impact of liquiritin on human keratinocyte HaCaT cell inflammatory damage …

Maresin 1 attenuates pro-inflammatory reactions and ER stress in HUVECs via PPARα-mediated pathway

TW Jung, HS Park, GH Choi, D Kim, SH Ahn… - Molecular and Cellular …, 2018 - Springer
The current study was designed to investigate the therapeutic effects of Maresin 1 (MAR1)
on atherosclerotic response. Human monocytes THP-1 and human umbilical vein …

MicroRNA-150 affects endoplasmic reticulum stress via MALAT1-miR-150 axis-mediated NF-κB pathway in LPS-challenged HUVECs and septic mice

L Liu, LN Yan, Z Sui - Life Sciences, 2021 - Elsevier
Aims Sepsis is a systemic inflammatory complication, which is the common cause of death in
critical patients. This study aimed to evaluate the potential regulatory mechanisms of miR …

MALAT1 modulates miR-146's protection of microvascular endothelial cells against LPS-induced NF-κB activation and inflammatory injury

LL Feng, WN Xin, XL Tian - Innate Immunity, 2019 - journals.sagepub.com
To investigate the role of miR-146 and its possible relationship with MALAT1 in LPS-induced
inflammation in human microvascular endothelial cells (HMECs), HMEC-1 cells were treated …