Maackiain suppresses the development of cervical cancer via AMPK priming autophagy

J He, L Xiang, T Zhu, H Wang, Y Huang… - Journal of Pharmacy …, 2024 - academic.oup.com
Abstract Background Maackiain (Mac), a flavonoid analog isolated from Sophora flavescens,
exhibits neuroprotective, anti-allergic, anti-inflammatory, and pro-apoptotic effects. It is not …

Maackiain inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by inhibiting the MAPK/Ras signaling pathway

X Jiang, Y Xiaonan, SHI Yanxia, L Yan… - Chinese Journal of …, 2023 - Elsevier
Nasopharyngeal carcinoma (NPC) is the third most common malignancy with a high
recurrence and metastasis rate in South China. Natural compounds extracted from …

Macleayins A From Macleaya Promotes Cell Apoptosis Through Wnt/β-Catenin Signaling Pathway and Inhibits Proliferation, Migration, and Invasion in Cervical …

C Sai, W Qin, J Meng, LN Gao, L Huang… - Frontiers in …, 2021 - frontiersin.org
Macleayins A (MA), a novel compound, was isolated from Macleaya cordata (Willd.) R. Br.
and Macleaya microcarpa (Maxim.) Fedde. The plant species are the member of …

Matrine exerts antitumor activity in cervical cancer by protective autophagy via the Akt/mTOR pathway in vitro and in vivo

F Zhang, H Zhang, W Qian, Y Xi… - Oncology …, 2022 - spandidos-publications.com
Matrine is a quinazoline alkaloid extracted from Sophora flavescens. The aim of the present
study was to determine whether matrine can induce autophagy in the human HeLa and …

Kaempferol Inhibits Cervical Cancer Cells by Inducing Apoptosis and Autophagy via Inactivation of the PI3K/AKT/mTOR Signaling Pathway

EY Choi, EJ Han, SJ Jeon, SW Lee, JM Moon… - Anticancer …, 2024 - ar.iiarjournals.org
Background/Aim: Kaempferol, a natural flavonoid, occurs abundantly in fruits and
vegetables. It has various bioactivities, with antioxidant, anti-inflammatory, and other …

Saikosaponin-A induces apoptosis of cervical cancer through mitochondria- and endoplasmic reticulum stress-dependent pathway in vitro and in vivo: involvement …

J Du, D Song, T Cao, Y Li, J Liu, B Li, L Li - Cell cycle, 2021 - Taylor & Francis
Cervical cancer causes considerable mortality in women worldwide. Saikosaponin-A, a
triterpenoid glycoside isolated from Bupleurum falcatum, has been proven to exert anti …

Curcumin derivative HBC induces autophagy through activating AMPK signal in A549 cancer cells

GZ Zhou, GC Sun, SN Zhang - Molecular & Cellular Toxicology, 2015 - Springer
Curcumin exhibits growth-suppressive activity against a variety of cancer cells, but low
bioavailability restricts its application in chemotherapeutic trials. A synthetic curcumin …

Curcumin induces autophagy via activating the AMPK signaling pathway in lung adenocarcinoma cells

K Xiao, J Jiang, C Guan, C Dong, G Wang… - Journal of …, 2013 - jstage.jst.go.jp
Curcumin is a major yellow pigment and active component of turmeric widely used as
dietary spice and herbal medicine. This compound has been reported to be a promising …

Ethoxysanguinarine, a novel direct activator of AMP-activated protein kinase, induces autophagy and exhibits therapeutic potential in breast cancer cells

Y Si, J Wang, X Liu, T Zhou, Y Xiang, T Zhang… - Frontiers in …, 2020 - frontiersin.org
Ethoxysanguinarine (Eth) is a benzophenanthridine alkaloid extracted from Macleaya
cordata (Willd) R. Br. It possesses antibacterial and antiviral activities and offers therapeutic …

Chaga mushroom extract induces autophagy via the AMPK-mTOR signaling pathway in breast cancer cells

MG Lee, YS Kwon, KS Nam, SY Kim, IH Hwang… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Chaga mushrooms (Inonotus obliquus) are
commonly used in traditional treatments in Eastern Europe and Asia due to their diverse …