The maintenance and regeneration of adult tissues rely on the self-renewal of stem cells.
Regeneration without over-proliferation requires precise regulation of the stem cell …

Stem cells maintain tissues by generating differentiated cell types while simultaneously self-
renewing their own population. The mechanisms that allow stem cell populations to function …

Understanding to what extent stem cell potential is a cell-intrinsic property or an emergent
behavior coming from global tissue dynamics and geometry is a key outstanding question of …

Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying
cells or to promote regeneration to repair damaged tissues. To perform these functions …

To maintain renewing epithelial tissues in a healthy, homeostatic state, cell divisions and
differentiation need to be tightly regulated. Mechanisms of homeostatic regulation often rely …

Stem cells are fundamental to human life and offer great therapeutic potential, yet their
biology remains incompletely—or in cases even poorly—understood. The field of stem cell …

How cell growth and proliferation are orchestrated in living tissues to achieve a given
biological function is a central problem in biology. During development, tissue regeneration …

Stem cells (SCs) perform the task of maintaining tissue homeostasis by both self-renewal
and differentiation. While it has been argued that SCs divide asymmetrically, there is also …

To maintain cycling adult tissue in homeostasis the balance between proliferation and
differentiation of stem cells needs to be precisely regulated. To investigate how stem cells …

Stem cell differentiation underlies many fundamental processes such as development,
tissue growth and regeneration, as well as disease progression. Understanding how stem …