The survival factor Bcl‐2 is a cyclic AMP response element‐binding protein (CREB) gene
product implicated in mediating some of estrogen's effects on neuroprotection. Previously …

In this study, we examined whether experimental alterations of circulating estrogen levels
are associated with changes in the expression of bcl-x, an inhibitor of apoptosis. We report …

BCL-2, a protein which negatively modulates apoptosis, is up-regulated by estrogen in
several tissues. To determine the effect of estradiol on Bcl-2 in the adult brain, its …

Recently we reported that chronic treatment with 17β-estradiol (E2) or tamoxifen (TAM)
regulates the ovariectomy-induced downregulation of the key molecules linked to …

Estradiol-17β is released from the ovaries in a cyclic manner during the normal estrous cycle
in rats. During the transition from the diestrous to proestrous stage, the 17β-estradiol …

Estrogen replacement therapy in menopausal women has been suggested to be beneficial
in preventing the progression of cognitive impairment in Alzheimer disease. We …

Clinical studies indicate an effect of estrogen (E2) on affect and cognition, which may be
mediated by the cyclic AMP response element-binding protein (CREB) pathway and CREB …

Actions of estrogen include mechanisms leading to alterations in gene transcription that may
be independent of nuclear estrogen receptors, as well as those involving direct action of the …

AIMS: The aim of the present study was to investigate the effects of different periods of
ovariectomy and 17β-estradiol replacement on apoptotic cell death and expression of …

The aim of the present study was to investigate the effects of different periods of ovariectomy
and 17β-estradiol (E2) replacement on the expression of Cytochrome C, apoptosis inducing …