Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout/mutated mice
SY Jiao, YH Yang, SR Chen - Human reproduction update, 2021 - academic.oup.com
BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
[HTML][HTML] The genetics of infertility: current status of the field
M Zorrilla, AN Yatsenko - Current genetic medicine reports, 2013 - Springer
Infertility is a relatively common health condition, affecting nearly 7% of all couples.
Clinically, it is a highly heterogeneous pathology with a complex etiology that includes …
Clinically, it is a highly heterogeneous pathology with a complex etiology that includes …
The biology of infertility: research advances and clinical challenges
Reproduction is required for the survival of all mammalian species, and thousands of
essential'sex'genes are conserved through evolution. Basic research helps to define these …
essential'sex'genes are conserved through evolution. Basic research helps to define these …
Male infertility: role of genetic background
Male infertility represents one of the clearest examples of a complex disease with a
substantial genetic basis. Numerous male mouse models, mutation screening and …
substantial genetic basis. Numerous male mouse models, mutation screening and …
Understanding the genetics of human infertility
Q Sang, PF Ray, L Wang - Science, 2023 - science.org
Reproduction involves a wide range of biological processes, including organ formation and
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …
Genetic causes of human reproductive disease
JC Achermann, G Ozisik, JJ Meeks… - The Journal of Clinical …, 2002 - academic.oup.com
Disorders of reproduction represent a significant social, medical, and economic burden for
individuals and society. Approximately 1 in 10 couples in the United States are infertile, and …
individuals and society. Approximately 1 in 10 couples in the United States are infertile, and …
[HTML][HTML] Meiosis interrupted: the genetics of female infertility via meiotic failure
Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …
A search for molecular mechanisms underlying male idiopathic infertility
A Bracke, K Peeters, U Punjabi, D Hoogewijs… - Reproductive …, 2018 - Elsevier
Infertility affects approximately 15% of the couples wanting to conceive. In 30− 40% of the
cases the aetiology of male infertility remains unknown and is called idiopathic male …
cases the aetiology of male infertility remains unknown and is called idiopathic male …
Disorders of spermatogenesis: perspectives for novel genetic diagnostics after 20 years of unchanged routine
F Tüttelmann, C Ruckert, A Röpke - Medizinische Genetik, 2018 - degruyter.com
Infertility is a common condition estimated to affect 10–15% of couples. The clinical causes
are attributed in equal parts to the male and female partners. Diagnosing male infertility …
are attributed in equal parts to the male and female partners. Diagnosing male infertility …
Testing for genetic contributions to infertility: potential clinical impact
Introduction: Male infertility affects about 7% of the general male population, and it is a
multifactorial, polygenic pathological condition. Known genetic factors, accounting for about …
multifactorial, polygenic pathological condition. Known genetic factors, accounting for about …