In the 1990s, the identification of a non-selective ion channel, especially responsive to
capsaicin, revolutionized the studies of somatosensation and pain that were to follow. The …

Historically, drug research targeted to pain treatment has focused on trying to prevent the
propagation of action potentials in the periphery from reaching the brain rather than …

TRPV1 is a polymodally activated cation channel acting as key receptor in nociceptive
neurons. Its function is strongly affected by kinase-mediated phosphorylation leading to …

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious
heat, capsaicin and other diverse stimuli. It is a nonselective cation channel that prefers …

TRPV1 has been originally cloned as the heat and capsaicin receptor implicated in acute
pain signalling, while further research has shifted the focus to its importance in chronic pain …

TRPV1 is a non-selective cation channel gated by noxious heat, vanilloids and extracellular
protons, and act as an important signal integrator in sensory nociceptors. Because of its …

Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that is
intensively expressed in the peripheral nerve system and involved in a variety of …

The transient receptor potential vanilloid type 1 receptor ion channel (TRPV1)(formerly
known as the “capsaicin receptor”) plays a crucial role in the excitation of the large …

The vanilloid receptor TRPV1 is now recognized as a molecular integrator of painful stimuli
ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of …

TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory
neurons involved in pain sensation and also at a number of other neuronal and non …