Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared
from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity …

Podophyllotoxin is an antimitotic natural product. Its inhibitory activity on cell growth led to
the development of the clinically valuable anticancer agents, etoposide, teniposide and the …

Podophyllum hexandrum Royle of family Berberidaceae is an endangered medicinal plant.
Rhizome of P. hexandrum contains several lignans which posses antitumor activity …

Derivatives of podophyllotoxin were prepared by coupling 10 FA with the C 4-α-hydroxy
function of podophyllotoxin. The coupling reactions between FA and podophyllotoxin were …

Podophyllotoxin is an important and much sought after antimitotic natural lead compound,
since it paved the way for three hemisynthetic derivatives of podophyllotoxin, eg, etoposide …

Podophyllotoxin and its related aryltetralin cyclolignans belong to a family of important
products that exhibit various biological properties (eg, cytotoxic, insecticidal, antifungal …

Podophyllotoxin is a naturally occurring lignan with important antineoplastic and antiviral
properties and supported by detailed understanding of their mechanism of action, and …

The lignan family of natural products includes compounds with important antineoplastic and
antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives …

The aryltetralin-type lignan podophyllotoxin, the main agent present in the resin extracted
from the rhizomes of different podophyllum species, possesses important antineoplastic and …

Several pinacol derivatives of podophyllotoxins bearing different side chains and functions
at C-7 were synthesized through reductive cross-coupling of podophyllotoxone and several …