DNA-editing enzymes perform chemical reactions on DNA nucleobases. These reactions
can change the genetic identity of the modified base or modulate gene expression. Interest …

RNA-guided programmable nucleases from CRISPR systems generate precise breaks in
DNA or RNA at specified positions. In cells, this activity can lead to changes in DNA …

Base editing is a genome editing strategy that induces specific single-nucleotide changes
within genomic DNA. Two major DNA base editors, cytosine base editors and adenine base …

CRISPR-mediated DNA base editors, which include cytosine base editors (CBEs) and
adenine base editors (ABEs), are promising tools that can induce point mutations at desired …

Programmable nucleases and deaminases, which include zinc-finger nucleases,
transcription activator-like effector nucleases, CRISPR RNA-guided nucleases, and RNA …

The past several years have seen an explosion in development of applications for the
CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to …

Clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editors
are powerful tools in biology and hold great promise for the treatment of human diseases …

RNA-guided nucleases of the CRISPR/Cas type can be repurposed as programmable
nucleotide deaminases to mediate targeted nucleotide substitutions. Such base editors have …

DNA deaminase enzymes play key roles in immunity and have recently been harnessed for
their biotechnological applications. In base editors (BEs), the combination of DNA …

Genome editing with CRISPR/Cas has rapidly gained popularity. Base editing, a new
CRISPR/Cas-based approach, can precisely convert one nucleotide to another in DNA or …