Theoretical modeling of endovascular drug delivery into a multilayer arterial wall from a drug-coated balloon
A Jain, S McGinty, G Pontrelli, L Zhou - … Journal of Heat and Mass Transfer, 2022 - Elsevier
Drug-coated balloons (DCBs) are used commonly for delivering drug into diseased arteries.
When applied on the inner surface of an artery, drug is transported from the balloon into the …
When applied on the inner surface of an artery, drug is transported from the balloon into the …
Computational model of drug-coated balloon delivery in a patient-specific arterial vessel with heterogeneous tissue composition
PK Mandal, Sarifuddin, VB Kolachalama - … engineering and technology, 2016 - Springer
Balloon angioplasty followed by local delivery of antiproliferative drugs to target tissue is
increasingly being considered for the treatment of obstructive arterial disease, and yet there …
increasingly being considered for the treatment of obstructive arterial disease, and yet there …
Effect of interstitial fluid flow on drug-coated balloon delivery in a patient-specific arterial vessel with heterogeneous tissue composition: A simulation study
Sarifuddin, PK Mandal - Cardiovascular Engineering and Technology, 2018 - Springer
Angioplasty with drug-coated balloons (DCBs) using excipients as drug carriers is emerging
as a potentially viable strategy demonstrating clinical efficacy and proposing additional …
as a potentially viable strategy demonstrating clinical efficacy and proposing additional …
[HTML][HTML] Does anisotropy promote spatial uniformity of stent-delivered drug distribution in arterial tissue?
S McGinty, M Wheel, S McKee, C McCormick - International Journal of Heat …, 2015 - Elsevier
In this article we investigate the role of anisotropic diffusion on the resulting arterial wall drug
distribution following stent-based delivery. The arterial wall is known to exhibit anisotropic …
distribution following stent-based delivery. The arterial wall is known to exhibit anisotropic …
[HTML][HTML] A decade of modelling drug release from arterial stents
S McGinty - Mathematical biosciences, 2014 - Elsevier
Drug-eluting stents have revolutionised the treatment of coronary artery disease. These
small medical devices have attracted much interest over the past decade from biologists …
small medical devices have attracted much interest over the past decade from biologists …
[HTML][HTML] Plaque heterogeneity and the spatial distributions of its components dictate drug-coated balloon therapy
Sarifuddin, PK Mandal - Scientific Reports, 2024 - nature.com
Drug-coated balloon (DCB) angioplasty is one of the potential approaches to alleviating in-
stent restenosis and treating peripheral artery disease. An in-silico model has been …
stent restenosis and treating peripheral artery disease. An in-silico model has been …
A mass transfer model of temporal drug deposition in artery walls
A new mass transfer model has been formulated and implemented for predicting the
penetration of liquid medication into an arterial wall. The model takes separate account of …
penetration of liquid medication into an arterial wall. The model takes separate account of …
[HTML][HTML] Controlling the rate of penetration of a therapeutic drug into the wall of an artery by means of a pressurized balloon
The focus of this paper is to propose, model, and characterize a means of accelerating the
rate of delivery of therapeutic drugs to human tissues. The investigated means is a …
rate of delivery of therapeutic drugs to human tissues. The investigated means is a …
[HTML][HTML] Intrinsic coating morphology modulates acute drug transfer in drug-coated balloon therapy
The hallmark of drug-coated balloon (DCB) therapy for the treatment of peripheral vascular
disease is that it allows for reopening of the narrowed lumen and local drug delivery without …
disease is that it allows for reopening of the narrowed lumen and local drug delivery without …
Mass transfer by advection and diffusion from a drug-eluting stent
JM Weiler, EM Sparrow, R Ramazani - … journal of heat and mass transfer, 2012 - Elsevier
Stents are often used to maintain the diameter of the coronary artery lumen. The insertion of
a stent into an artery often results in the accumulation of scar tissue in response to the stent's …
a stent into an artery often results in the accumulation of scar tissue in response to the stent's …
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