Theoretical modeling of endovascular drug delivery into a multilayer arterial wall from a drug-coated balloon

A Jain, S McGinty, G Pontrelli, L Zhou - … Journal of Heat and Mass Transfer, 2022 - Elsevier
Drug-coated balloons (DCBs) are used commonly for delivering drug into diseased arteries.
When applied on the inner surface of an artery, drug is transported from the balloon into the …

Computational model of drug-coated balloon delivery in a patient-specific arterial vessel with heterogeneous tissue composition

PK Mandal, Sarifuddin, VB Kolachalama - … engineering and technology, 2016 - Springer
Balloon angioplasty followed by local delivery of antiproliferative drugs to target tissue is
increasingly being considered for the treatment of obstructive arterial disease, and yet there …

Effect of interstitial fluid flow on drug-coated balloon delivery in a patient-specific arterial vessel with heterogeneous tissue composition: A simulation study

Sarifuddin, PK Mandal - Cardiovascular Engineering and Technology, 2018 - Springer
Angioplasty with drug-coated balloons (DCBs) using excipients as drug carriers is emerging
as a potentially viable strategy demonstrating clinical efficacy and proposing additional …

[HTML][HTML] Does anisotropy promote spatial uniformity of stent-delivered drug distribution in arterial tissue?

S McGinty, M Wheel, S McKee, C McCormick - International Journal of Heat …, 2015 - Elsevier
In this article we investigate the role of anisotropic diffusion on the resulting arterial wall drug
distribution following stent-based delivery. The arterial wall is known to exhibit anisotropic …

[HTML][HTML] A decade of modelling drug release from arterial stents

S McGinty - Mathematical biosciences, 2014 - Elsevier
Drug-eluting stents have revolutionised the treatment of coronary artery disease. These
small medical devices have attracted much interest over the past decade from biologists …

[HTML][HTML] Plaque heterogeneity and the spatial distributions of its components dictate drug-coated balloon therapy

Sarifuddin, PK Mandal - Scientific Reports, 2024 - nature.com
Drug-coated balloon (DCB) angioplasty is one of the potential approaches to alleviating in-
stent restenosis and treating peripheral artery disease. An in-silico model has been …

A mass transfer model of temporal drug deposition in artery walls

JP Abraham, JM Gorman, EM Sparrow, JR Stark… - International Journal of …, 2013 - Elsevier
A new mass transfer model has been formulated and implemented for predicting the
penetration of liquid medication into an arterial wall. The model takes separate account of …

[HTML][HTML] Controlling the rate of penetration of a therapeutic drug into the wall of an artery by means of a pressurized balloon

JR Stark, JM Gorman, EM Sparrow, JP Abraham… - 2013 - scirp.org
The focus of this paper is to propose, model, and characterize a means of accelerating the
rate of delivery of therapeutic drugs to human tissues. The investigated means is a …

[HTML][HTML] Intrinsic coating morphology modulates acute drug transfer in drug-coated balloon therapy

GH Chang, DA Azar, C Lyle, VC Chitalia, T Shazly… - Scientific Reports, 2019 - nature.com
The hallmark of drug-coated balloon (DCB) therapy for the treatment of peripheral vascular
disease is that it allows for reopening of the narrowed lumen and local drug delivery without …

Mass transfer by advection and diffusion from a drug-eluting stent

JM Weiler, EM Sparrow, R Ramazani - … journal of heat and mass transfer, 2012 - Elsevier
Stents are often used to maintain the diameter of the coronary artery lumen. The insertion of
a stent into an artery often results in the accumulation of scar tissue in response to the stent's …