Objective: To determine the current best practice for treatment of infantile spasms in children.
Methods: Database searches of MEDLINE from 1966 and EMBASE from 1980 and searches …

Up-to date information about corticotropin (ACTH) in the treatment of infantile spasms and
evaluation of the long-term outcome was provided to answer questions about (1) the efficacy …

Children with infantile spasms are likely to have a poor outcome. Outcome measures for
infantile spasms include primary response to treatment, relapse of spasms, neurological …

The treatment of infantile spasms is challenging, especially in the context of the following:(1)
a severe phenotype with high morbidity and mortality;(2) the urgency of diagnosis and …

Objective: To update the 2004 American Academy of Neurology/Child Neurology Society
practice parameter on treatment of infantile spasms in children. Methods: MEDLINE and …

PURPOSE: The goal of this retrospective study is to review the causes of infantile spasms
and to correlate aetiology with outcome. METHODS: All children diagnosed with infantile …

Purpose: To compare the efficacy and tolerability of vigabatrin (VGB) and
adrenocorticotrophic hormone (ACTH) as first‐line therapy in infantile spasms. Methods …

Purpose: The efficacy of a protocol consisting of vigabatrin (VGB) as the first and
adrenocorticotropic hormone (ACTH) or valproate (VPA) as the second drug was studied in …

The accurate determination of etiology is now becoming increasingly possible. There is still
a lack of consensus about the treatment of first choice for infantile spasms. However, recent …

A large randomized study was conducted in patients with newly diagnosed infantile spasms
to compare 2 doses of vigabatrin in achieving spasm cessation. High (100-148 mg/kg/d) and …