The circadian clock is an evolutionarily highly conserved endogenous timing program that
structures physiology and behavior according to the time of day. Disruption of circadian …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Epidemiological studies provided the first evidence suggesting a connection between the
circadian clock and human health. Mutant mice convincingly demonstrate the principle that …

The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

The last 20 years have seen the rapid evolution of our understanding of the molecular genes
and networks that enable almost all forms of life to generate 24-hour—or circadian …

The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

Daily rhythms in behavior, physiology, and metabolism are an integral part of homeostasis.
These rhythms emerge from interactions between endogenous circadian clocks and …

Circadian rhythm disorders have been classically associated with disorders of abnormal
timing of the sleep–wake cycle, however circadian dysfunction can play a role in a wide …

The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …

Circadian disruption is pervasive and can occur at multiple organizational levels,
contributing to poor health outcomes at individual and population levels. Evidence points to …