Abstract 'Smart'bioresponsive materials that are sensitive to biological signals or to
pathological abnormalities, and interact with or are actuated by them, are appealing …

Smart or stimuli-responsive materials are an emerging class of materials used for tissue
engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state …

Smart biomaterials have the ability to respond to changes in physiological parameters and
exogenous stimuli and continue to impact many aspects of modern medicine. Smart …

Nature employs a variety of tactics to precisely time and execute the processes and
mechanics of life, relying on sequential sense and response cascades to transduce …

Materials that respond to endogenous stimuli are being leveraged to enhance
spatiotemporal control in a range of biomedical applications from drug delivery to diagnostic …

Biomaterials that interface with biological systems are used to deliver drugs safely and
efficiently; to prevent, detect, and treat disease; to assist the body as it heals; and to engineer …

Cells in the body reside within the extracellular matrix (ECM), a three-dimensional
environment that not only provides structural support for the cells, but also influences cellular …

▪ Abstract Since its inception just over a half century ago, the field of biomaterials has seen a
consistent growth with a steady introduction of new ideas and productive branches. This …

Over the past 10 years, stimuli-responsive polymeric biomaterials have emerged as effective
systems for the delivery of therapeutics. Persistent with ongoing efforts to minimize adverse …

The cell microenvironment choreographs the behaviors of cells through multiple well-
controlled signals. For basic biological study and cell-based therapies, it is essential to …