Chronotherapeutics refers to treatments based on the principles of circadian rhythm
organization and sleep physiology, which control the exposure to environmental stimuli that …

Chronobiological therapies for mood disorders include manipulations of the sleep–wake
cycle such as sleep deprivation and sleep phase advance and the controlled exposure to …

Alteration of the sleep–wake cycle and of the sleep structure are core symptoms of a major
depressive episode, and occur both in course of bipolar disorder and of major depressive …

Psychiatric chronotherapeutics is the controlled exposure to environmental stimuli that act
on biological rhythms in order to achieve therapeutic effects in the treatment of psychiatric …

Scientific evidence that circadian rhythms affect pharmacokinetics and pharmacodynamics
has highlighted the importance of drug dosing-time. Circadian oscillations alter drug …

The proportion of diagnosed depressives prescribed antidepressants has increased
markedly over the last 20 years, mainly following the introduction of the selective serotonin …

In humans almost all physiological and behavioural functions occur on a rhythmic basis.
Therefore the possibility that delays, advances or desynchronizations of circadian rhythms …

Circadian rhythms are near 24-h cycles in a number of physiological and behavioural
parameters and the underpinning circadian timing systems is one of the key homeostatic …

Depressive disorders are associated with various neurobiological alterations like
hyperactivity of the hypothalamic-pituitary-adrenal axis, altered neuroplasticity and altered …

Depressive syndromes are frequent and heterogeneous brain conditions with more than
90% of patients suffering from sleep complaints. Better characterizing this “sleep” domain …