The cell as a dynamical system presents the characteristics of having a dynamical structure.
That is, the exact phase space of the system cannot be fixed before the evolution and …

MGS is an experimental programming language for the modeling and the simulation of
discrete dynamical systems. The modeling approach is based on the explicit specification of …

MGS is an experimental programming language dedicated to the modeling and the
simulation of a special kind of discrete dy-namical systems. Dynamical systems with a …

In this paper, we aim at modeling and analyzing the regulation processes in multi-cellular
biological systems, in particular, tissues. The modeling framework is a generalization of …

Motivation: Need for software to setup and analyze complex mathematical models for
cellular systems in a modular way, that also integrates the experimental environment of the …

Systems theory and cell biology have enjoyed a long relationship that has received renewed
interest in recent years in the context of systems biology. The term 'systems' in systems …

Agent-based models are rigorous tools for simulating the interactions of individual entities,
such as organisms or molecules within cells and assessing their effects on the dynamic …

Interactions among cellular constituents play a crucial role in overall cellular function and
organization. These interactions can be viewed as being complementary to the usual “parts …

Assembly of quantitative models of large complex networks brings about several challenges.
One of them is the combinatorial complexity, where relatively few signalling molecules can …

Biochemical network modeling and simulation is an essential task in any systems biology
project. The systems biology markup language (SBML) was established as a standardized …