Appropriate anticoagulation for hemodialysis (HD) requires a subtle balance between under‐
and over‐heparinization to prevent extracorporeal circuit (ECC) clotting and bleeding …

Systemic anticoagulation in maintenance hemodialysis (HD) has historically been
considered necessary to maintain the extracorporeal circuit (ECC) and preserve dialysis …

The coagulation cascade is complex but well studied. Dialysis membranes and lines are
inherently pro‐coagulant and activate both the intrinsic and extrinsic pathways of …

Anticoagulation is essential to hemodialysis, and unfractionated heparin (UFH) is the most
commonly used anticoagulant in the United States. However, there is no universally …

Objective In this clinical trial, we aimed to compare three means of performing chronic
hemodialysis in patients with contra-indication to systemic heparinization. Methods This …

Numerous acquired hemostatic abnormalities have been identified in renal insufficiency.
Hemodialysis procedures add to these disturbances as they repetitively imply turbulent …

Evidence on the optimal anticoagulation regimen for hemodialysis in patients at high
bleeding risk is scarce. The HepZero study is the first large multinational study comparing …

Background Anticoagulation for chronic dialysis patients with contraindications to heparin
administration is challenging. Current guidelines state that in patients with increased …

Heparin is the most widely used anticoagulant for maintaining patency of the extracorporeal
blood circuit during intermittent hemodialysis. Inadvertently, this leads to systemic …

Unfractionated heparin remains the most commonly used anticoagulant for extracorporeal
therapies worldwide due to cost, years of clinical experience showing effectiveness and …