Chemotherapeutics occupy a pivotal role in the medication of different types of cancers, but
the prevalence and mortality rates of cancer remain high. The drug resistance and low …

The search for new anticancer agents is considered a dynamic field of medicinal chemistry.
In recent years, the synthesis of compounds with anticancer potential has increased and a …

Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical
structures that confer them with a broad spectrum of pharmacological activities. They have …

Pyrazole is a five-membered heterocyclic compound containing two nitrogen atoms. Due to
its biological significance, design of novel pyrazole derivatives has become an interesting …

Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C 3
H 3 N 2 H. The presence of this nucleus in pharmacological agents of various therapeutic …

We designed and synthesized new pyrazole thiourea chimeric derivatives and confirmed
their structures by NMR and IR spectra. Apoptotic effects were studied in human cancer …

Pyrazole is a versatile lead compound to design potent bioactive molecules for drug
discovery and development, particularly in cancer therapy. The aim of this review is to …

Cancers are already placing an enormous load on the worldwide healthcare practice; so,
anti-neoplastic compounds nowadays are most essential in cancer remedy. Nevertheless …

The drug resistance and low specificity of current available chemotherapeutics to cancer
cells are the main reasons responsible for the failure of cancer chemotherapy and remain …

Pyrazole has been the topic of interest for thousands of researchers across the world
because of its wide spectrum pharmacological activities. Various structural modifications of …