Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases

M Sun, W Jiang, N Mu, Z Zhang, L Yu, H Ma - Journal of Translational …, 2023 - Springer
Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related
death worldwide, and effective therapeutic strategies against CVD are urgently needed …

[HTML][HTML] Mitochondrial transfer in cardiovascular disease: from mechanisms to therapeutic implications

J Chen, J Zhong, L Wang, Y Chen - Frontiers in Cardiovascular …, 2021 - frontiersin.org
Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of
cardiovascular diseases. The phenomenon of intercellular mitochondrial transfer has been …

Current advances of Mitochondrial dysfunction and cardiovascular disease and promising therapeutic strategies

D Xia, Y Liu, P Wu, D Wei - The American journal of pathology, 2023 - Elsevier
Mitochondria are “cellular power stations” and essential organelles for maintaining cellular
homeostasis. Dysfunctional mitochondria have emerged as a key factor in the occurrence …

Unlocking the secrets of mitochondria in the cardiovascular system: path to a cure in heart failure—a report from the 2018 National Heart, Lung, and Blood Institute …

R Tian, WS Colucci, Z Arany, MM Bachschmid… - Circulation, 2019 - Am Heart Assoc
Mitochondria have emerged as a central factor in the pathogenesis and progression of heart
failure, and other cardiovascular diseases, as well, but no therapies are available to treat …

[HTML][HTML] Mitochondrial transplantation: the advance to therapeutic application and molecular modulation

JD McCully, PJ Del Nido, SM Emani - Frontiers in Cardiovascular …, 2023 - ncbi.nlm.nih.gov
Mitochondrial transplantation provides a novel methodology for rescue of cell viability and
cell function following ischemia-reperfusion injury and applications for other pathologies are …

Mitochondrial transplantation as a novel therapeutic strategy for mitochondrial diseases

A Park, M Oh, SJ Lee, KJ Oh, EW Lee, SC Lee… - International journal of …, 2021 - mdpi.com
Mitochondria are the major source of intercellular bioenergy in the form of ATP. They are
necessary for cell survival and play many essential roles such as maintaining calcium …

Mitochondrial dysfunction in cardiac diseases and therapeutic strategies

Y Huang, B Zhou - Biomedicines, 2023 - mdpi.com
Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for
various physiological activities of the cell. Cardiomyocytes have a high density of …

Extracellular mitochondrial components and effects on cardiovascular disease

Y Xu, Y Yu, B Yang, J Hui, C Zhang, H Fang… - DNA and Cell …, 2021 - liebertpub.com
Besides being powerhouses of the cell, mitochondria released into extracellular space act
as intercellular signaling. Mitochondria and their components mediate cell-to-cell …

[HTML][HTML] Delivery of mitochondria confers cardioprotection through mitochondria replenishment and metabolic compliance

A Zhang, Y Liu, J Pan, F Pontanari, ACH Chang… - Molecular Therapy, 2023 - cell.com
Mitochondrial dysfunction is a hallmark of heart failure. Mitochondrial transplantation has
been demonstrated to be able to restore heart function, but its mechanism of action remains …

[HTML][HTML] Mitochondrial dysfunction in cardiovascular diseases: potential targets for treatment

J Yang, Q Guo, X Feng, Y Liu, Y Zhou - Frontiers in cell and …, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are serious problems that threaten public health and are
responsible for nearly one-third of global deaths. Mitochondrial dysfunction is accountable …