The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

The endoplasmic reticulum (ER) is a central organelle for protein biosynthesis, folding, and
traffic. Perturbations in ER homeostasis create a condition termed ER stress and lead to …

Endoplasmic reticulum (ER) stress, a change in the ER homeostasis, leads to initiation of the
unfolded protein response (UPR). The primary functions of the UPR are to restore the ER's …

Increased demand on the protein folding capacity of the endoplasmic reticulum (ER)
engages an adaptive reaction known as the unfolded protein response (UPR). The UPR …

In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of
homeostasis causes stress. In this review I summarize how perturbation of three major …

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

The endoplasmic reticulum (ER) is the principal cellular organelle in which correct folding
and maturation of transmembrane, secretory, and ER-resident proteins occur. Research …

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and
secretory activities in the cell. Alterations in ER homeostasis cause accumulation of …

Numerous genetic and environmental insults impede the ability of cells to properly fold and
posttranslationally modify secretory and transmembrane proteins in the endoplasmic …

The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking
and is central to many cellular functions. Failure of the ER's adaptive capacity results in …