An overview of the application of natural and synthetic, non-viral vectors for oligonucleotide
delivery into the lung is presented in this review, with a special focus on lung cancer. Due to …

Research on siRNA is increasing due to its wide applicability as a therapeutic agent in
irreversible medical conditions. siRNA inhibits expression of the specific gene after its …

RNA interference (RNAi) is an important part of the cell's defenses against viruses and other
foreign genes. Moreover, the biotechnological exploitation of RNAi offers therapeutic …

This article reviews the pulmonary route of administration, aerosol delivery devices,
characterization of pulmonary drug delivery systems, and discusses the rationale for inhaled …

In this article, applications of engineered nanoparticles containing siRNA for inhalation
delivery are reviewed and discussed. Diseases with identified protein malfunctions may be …

The pulmonary delivery of drugs is the most striking target and of incredible scientific and
biomedical attention in the research of health care because the lung is able to absorb …

RNA interference (RNAi) is gaining increasing popularity both as a molecular biology tool
and as a potential therapeutic agent. RNAi is a naturally occurring gene regulatory …

Small interfering RNA (siRNA) has a huge potential for the treatment or prevention of various
lung diseases. Once the RNA molecules have successfully entered the target cells, they …

Lung diseases are a leading cause of mortality worldwide and there exists urgent need for
new therapies. Approval of the first siRNA treatments in humans has opened the door for …

SiRNAs exert their biological effect by guiding the degradation of their cognate mRNA
sequence, thereby shutting down the corresponding protein production (gene silencing by …